Dr Jenna Gregory (MB BChir, PhD, MMedSci, MSc, BSc)

SCREDS Clinical Lecturer


I am a SCREDS Clinical Lecturer and Pathologist working in the DRI in Edinburgh. My research focuses on understanding the pathophysiology and molecular landscape of amyotrophic lateral sclerosis and frontotemporal dementia. My human experimental research programme implements state of the art molecular techniques allied to human pathological material with linked rich clinical phenotypic and genetic information.

Research summary

My recent work has involved the implementation of cutting-edge technologies to probe, potentially pathogenic, transcriptional variations in individuals with amyotrophic lateral sclerosis and frontotemporal dementia spectrum disorder (ALS-FTD) using post-mortem brain tissue. Using these techniques, we have been able to preserve spatial resolution, identifying (i) cell-type specific and (ii) brain region-specific differences in key RNA transcripts that may account for regional susceptibilities to the disease process seen in individuals with ALS-FTD. These findings, combined with access to linked clinical records will hopefully allow us to explore clinico-pathological correlations with the aim of identifying novel therapeutic targets and developing novel biomarkers necessary for clinical trials in this field.

View all 23 publications on Research Explorer