Dr Jason Mooney
Research & Teaching Fellow, Principal Investigator
- College of Science and Engineering
- School of Biological Sciences
- Institute for Immunology and Infection Research
Contact details
- Email: Jason.Mooney@ed.ac.uk
Address
- Street
-
Ashworth Laboratories
King’s Buildings - City
- Edinburgh
- Post code
- EH9 3FL
Qualifications
BSc - Microbiology, University of Tennessee (2006)
PhD - Immunology, University of California Davis (2015)
Research summary
My primary interest is in invasive bacterial infections – how they overcome the innate physical and immunological barriers at mucosal surfaces to invade the tissues and then how they evade systemic immune responses to establish a niche for replication. My current work focuses on malaria co-infection as a risk factor for invasive bacterial disease, specifically the role of coinfection in loss of intestinal integrity and disruption of neutrophil-mediated containment of Salmonella. This research has led to work in animal models (rodent, porcine, non-human primate) and clinical cohorts (UK and The Gambia).
-
Dry season prevalence of plasmodium falciparum in asymptomatic Gambian children, with a comparative evaluation of diagnostic methods
In:
Malaria Journal
Research output: Contribution to Journal › Article (Accepted/In press) -
‘Bouncing back’ from subclinical malaria: Inflammation and erythrocytosis after resolution of P. falciparum infection in Gambian children
In:
Frontiers in Immunology
Research output: Contribution to Journal › Article (Accepted/In press) -
A Conserved TCRβ signature dominates a highly polyclonal T-cell expansion during the acute phase of a murine malaria infection
(18 pages)
In:
Frontiers in Immunology, vol. 11
DOI: https://doi.org/10.3389/fimmu.2020.587756
Research output: Contribution to Journal › Article (Published) -
Does malaria cause diarrhoea? A systematic review
(16 pages)
In:
Frontiers in Medicine, vol. 7
DOI: https://doi.org/10.3389/fmed.2020.589379
Research output: Contribution to Journal › Review article (Published) -
An enhanced toolkit for the generation of knockout and marker-free fluorescent Plasmodium chabaudi
In:
Wellcome Open Research , vol. 5, pp. 71
DOI: https://doi.org/10.12688/wellcomeopenres.15587.2
Research output: Contribution to Journal › Article (Published) -
Natural Killer cells dampen the pathogenic features of recall responses to influenza infection
In:
Frontiers in Immunology
DOI: https://doi.org/10.3389/fimmu.2020.00135
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Influenza Vaccination Primes Human Myeloid Cell Cytokine Secretion and NK Cell Function
In:
Journal of Immunology
DOI: https://doi.org/10.4049/jimmunol.1801648
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Malaria, anemia and invasive bacterial disease: a neutrophil problem?
In:
Journal of Leukocyte Biology
DOI: https://doi.org/10.1002/JLB.3RI1018-400R
Research output: Contribution to Journal › Article (Published) -
Relationship between Anaemia, Haemolysis, Inflammation and Haem Oxygenase-1 at Admission with Sepsis: a pilot study
In:
Scientific Reports, vol. 8, pp. 11198
DOI: https://doi.org/10.1038/s41598-018-29558-5
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Haemolysis and haem oxygenase-1 induction during persistent "asymptomatic" malaria infection in Burkinabé children
In:
Malaria Journal, vol. 17, pp. 253
DOI: https://doi.org/10.1186/s12936-018-2402-6
Research output: Contribution to Journal › Article (Published)