Dr James Glover
Chancellor's Fellow
Contact details
Address
- Street
-
The Roslin Institute
Easter Bush Campus
Midlothian - City
- Post code
- EH25 9RG
Research summary
The generation of structure from an initially homogeneous state, such as how an entire organism is developed from a single fertilised egg, is an enduring and fascinating scientific question. During embryonic development, the generation of spatially distinct repeating elements is essential for the correct function of many tissues and organs. These arrangements are called periodic patterns and are usually observed as spots or stripes. Forming autonomously from an initially homogenous state periodic patterns include the digits of the limb, the appendages of the skin including hair follicles, feathers and fingerprints, and the villi of the intestine. However, developmental disorders associated with disruption of these patterning events occur in all species, including humans and livestock, and affects multiple processes including skeletogenesis, gut formation and skin development.
Our research group is interested in how periodic patterns are produced during embryogenesis, with a particular focus on decoupling the influences of the molecular and mechanoceullar environment on these processes. We take a multidisciplinary approach incorporating aspects of several fields including cell biology, developmental biology, mathematics and engineering, using the chick embryo as our primary model. Our goal is to understand the core processes which drive vertebrate periodic pattern formation to provide insight into the causality of associated birth disorders and help guide future regenerative medicine strategies.
Current research interests
Periodic patterning during vertebrate development. Tracheal formation. Development of novel avian transgenic technologiesPast research interests
Fingerprint pattern formation, hair follicle patterning, mammalian skin development, primordial germ cell migration and specification.-
The Developmental Basis of Fingerprint Pattern Formation and Variation
In:
Cell, vol. 186, pp. 1-17
DOI: https://doi.org/10.1016/j.cell.2023.01.015
Research output: Contribution to Journal › Article (Published) -
The EDA deficient mouse has Zymbal’s gland hypoplasia and acute otitis externa
In:
Disease Models and Mechanisms, vol. 15
DOI: https://doi.org/10.1242/dmm.049034
Research output: Contribution to Journal › Article (Published) -
Limb development genes underlie variation in human fingerprint patterns
In:
Cell, vol. 185, pp. 95-112.e18
DOI: https://doi.org/10.1016/j.cell.2021.12.008
Research output: Contribution to Journal › Article (Published) -
Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations.
In:
Nature Communications, vol. 10
DOI: https://doi.org/10.1038/s41467-019-11053-8
Research output: Contribution to Journal › Article (Published) -
Chronic otitis media is initiated by a bulla cavitation defect in the FBXO11 mouse model
In:
Disease Models and Mechanisms, vol. 12, pp. 1-10
DOI: https://doi.org/10.1242/dmm.038315
Research output: Contribution to Journal › Article (Published) -
Feather arrays are patterned by interacting signalling and cell density waves
(38 pages)
In:
PLoS Biology, vol. 17, pp. 1-38
DOI: https://doi.org/10.1371/journal.pbio.3000132
Research output: Contribution to Journal › Article (Published) -
Hierarchical patterning modes orchestrate hair follicle morphogenesis
(32 pages)
In:
PLoS Biology, vol. 15, pp. 1-31
DOI: https://doi.org/10.1371/journal.pbio.2002117
Research output: Contribution to Journal › Article (Published) -
FGF, Insulin, and SMAD Signaling Cooperate for Avian Primordial Germ Cell Self-Renewal
In:
Stem Cell Reports, vol. 5, pp. 1171–1182
DOI: https://doi.org/10.1016/j.stemcr.2015.10.008
Research output: Contribution to Journal › Article (Published) -
Maintenance of Distinct Melanocyte Populations in the Interfollicular Epidermis
In:
Pigment Cell & Melanoma Research, vol. 28, pp. 476-480
DOI: https://doi.org/10.1111/pcmr.12375
Research output: Contribution to Journal › Article (Published) -
Deficiency of the bone mineralization inhibitor NPP1 protects against obesity and diabetes
(10 pages)
In:
Disease Models and Mechanisms, vol. 7, pp. 1341-1350
DOI: https://doi.org/10.1242/dmm.017905
Research output: Contribution to Journal › Article (Published) -
Culturing avian primordial germ cells and novel transposon vectors for transgenesis
(1 page)
In:
Transgenic Research, vol. 23, pp. 193-193
DOI: https://doi.org/10.1007/s11248-013-9761-0
Research output: Contribution to Journal › Meeting abstract (Published) -
A novel piggybac transposon inducible expression system identifies a role for akt signalling in primordial germ cell migration
In:
PLoS ONE, vol. 8
DOI: https://doi.org/10.1371/journal.pone.0077222
Research output: Contribution to Journal › Article (Published) -
Primordial Germ Cell Technologies for Avian Germplasm Cryopreservation and Investigating Germ Cell Development
(8 pages)
In:
The Journal of Poultry Science, vol. 49, pp. 155-162
DOI: https://doi.org/10.2141/jpsa.011161
Research output: Contribution to Journal › Article (Published) -
Investigating the role of PRDM14 in avian germ cell development using an inducible transposon system
Research output: Contribution to Conference › Abstract (Published) -
Characterisation and germline transmission of cultured avian primordial germ cells
(10 pages)
In:
PLoS ONE, vol. 5
DOI: https://doi.org/10.1371/journal.pone.0015518
Research output: Contribution to Journal › Article (Published)