Dr Georg Kustatscher
Research Group Leader
- Institute of Quantitative Biology, Biochemistry and Biotechnology
- School of Biological Sciences
Contact details
- Email: georg.kustatscher@ed.ac.uk
Address
- Street
-
4.15 Michael Swann Building
King's Buildings
Max Born Crescent - City
- Edinburgh
- Post code
- EH9 3BF
Background
Dr Kustatscher is a Group leader and MRC Career Development Fellow at the Insitute for Quantitative Biology, Biochemistry and Biotechnology, Edinburgh.
He studied Molecular Biology at the University of Salzburg, Austria, and obtained a PhD from the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, working on epigenetics in the lab of Andreas Ladurner.
From 2008 to 2020 he was a Postdoc in Juri Rappsilber’s group at the Wellcome Centre for Cell Biology (WCB) in Edinburgh, combining proteomics and computational approaches to understand how cells regulate mRNA and protein levels from a systems perspective.
Research summary
Systems Biology
Proteomics
Computational Biology
Integration of "omics" data
Current research interests
The aim of my lab is to understand how cells regulate protein levels, and how these processes are disrupted in cancer cells. We address this question by combining proteomics, transcriptomics and computational approaches, including machine-learning.Current project grants
How cells regulate protein levels (and fail to do so in cancer)
Medical Research Council (MRC) Career Development Award
Grant number: MR/T03050X/1
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Mapping the invisible chromatin transactions of prophase chromosome remodeling
(13 pages)
In:
Molecular Cell, vol. 82, pp. 696-708.e4
DOI: https://doi.org/10.1016/j.molcel.2021.12.039
Research output: Contribution to Journal › Article (Published) -
Low cell number proteomic analysis using in-cell protease digests reveals a robust signature for cell cycle state classification
(19 pages)
In:
Molecular and Cellular Proteomics, vol. 21
DOI: https://doi.org/10.1016/j.mcpro.2021.100169
Research output: Contribution to Journal › Article (Published) -
Mapping the invisible chromatin transactions of prophase chromosome remodelling
In:
Molecular Cell
Research output: Contribution to Journal › Article (Accepted/In press) -
Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination
(16 pages)
In:
Molecular Cell, vol. 81, pp. P1084-1099.E6
DOI: https://doi.org/10.1016/j.molcel.2020.12.025
Research output: Contribution to Journal › Article (Published) -
Co-regulation map of the human proteome enables identification of protein functions
(11 pages)
In:
Nature Biotechnology, vol. 37, pp. 1361-1371
DOI: https://doi.org/10.1038/s41587-019-0298-5
Research output: Contribution to Journal › Article (Published)