Dr Christopher W. Wood
Lecturer in Biotechnology
- Centre for Engineering Biology
- Institute of Quantitative Biology, Biochemistry and Biotechnology
- School of Biological Sciences
Contact details
- Email: chris.wood@ed.ac.uk
- Web: Group Website
Address
- Street
-
3.03 Alrick Building
Max Born Crescent
King's Buildings - City
- Edinburgh
- Post code
- EH9 3BF
Background
2020 Lecturer in Biotechnology, University of Edinburgh
2018 EPSRC Postdoctoral Research Fellow, University of Edinburgh
2016 Postdoctoral Researcher, Woolfson Group, University of Bristol
Qualifications
2016 DPhil. Biochemistry, University of Bristol
2013 BSc. (Hons) Molecular and Cellular Biology, University of Glasgow
Research summary
Our research focuses on improving the accessibility and reliability of protein design, with the aim of increasing its use as a tool for tackling challenges in biotechnology and synthetic biology. To do this, we're developing software that applies machine-learning, computational modelling and structural bioinformatics to help guide users through the protein-design process.
Current research interests
Protein design, protein structure, structural bioinformatics, machine learning, experimental automation.Affiliated research centres
-
Differential sensing with arrays of de novo designed peptide assemblies
(12 pages)
In:
Nature Communications, vol. 14
DOI: https://doi.org/10.1038/s41467-023-36024-y
Research output: Contribution to Journal › Article (Published) -
Generation of photocaged nanobodies for intracellular applications in an animal using genetic code expansion and computationally guided protein engineering**
(11 pages)
In:
ChemBioChem, vol. 23
DOI: https://doi.org/10.1002/cbic.202200321
Research output: Contribution to Journal › Article (Published) -
DE-STRESS: A user-friendly web application for the evaluation of protein designs
(6 pages)
In:
Protein Engineering, Design & Selection (PEDS), vol. 34
DOI: https://doi.org/10.1093/protein/gzab029
Research output: Contribution to Journal › Article (Published) -
PDBench: Evaluating Computational Methods for Protein Sequence Design
(20 pages)
Research output: › Preprint (Published) -
De novo designed peptide and protein hairpins self‐assemble into sheets and nanoparticles
(11 pages)
In:
Small
DOI: https://doi.org/10.1002/smll.202100472
Research output: Contribution to Journal › Article (E-pub ahead of print) -
BAlaS: Fast, interactive and accessible computational alanine-scanning using BudeAlaScan
In:
Bioinformatics, vol. 36, pp. 2917-2919
DOI: https://doi.org/10.1093/bioinformatics/btaa026
Research output: Contribution to Journal › Article (Published) -
Peptide assembly directed and quantified using megadalton DNA nanostructures
(9 pages)
In:
ACS Nano, vol. 13, pp. 9927-9935
DOI: https://doi.org/10.1021/acsnano.9b04251
Research output: Contribution to Journal › Article (Published) -
Navigating the structural landscape of de Novo α-helical bundles
(11 pages)
In:
Journal of the American Chemical Society, vol. 141, pp. 8787-8797
DOI: https://doi.org/10.1021/jacs.8b13354
Research output: Contribution to Journal › Article (Published) -
Maintaining and breaking symmetry in homomeric coiled-coil assemblies
In:
Nature Communications, vol. 9
DOI: https://doi.org/10.1038/s41467-018-06391-y
Research output: Contribution to Journal › Article (Published) -
Applying graph theory to protein structures: An atlas of coiled coils
(8 pages)
In:
Bioinformatics, vol. 34, pp. 3316-3323
DOI: https://doi.org/10.1093/bioinformatics/bty347
Research output: Contribution to Journal › Article (Published) -
Chimeric streptavidins as host proteins for artificial metalloenzymes
(9 pages)
In:
ACS Catalysis, vol. 8, pp. 1476-1484
DOI: https://doi.org/10.1021/acscatal.7b03773
Research output: Contribution to Journal › Article (Published) -
CCBuilder 2.0: Powerful and accessible coiled-coil modeling
(9 pages)
In:
Protein Science, vol. 27, pp. 103-111
DOI: https://doi.org/10.1002/pro.3279
Research output: Contribution to Journal › Article (Published) -
ISAMBARD: An open-source computational environment for biomolecular analysis, modelling and design
(8 pages)
In:
Bioinformatics, vol. 33, pp. 3043-3050
DOI: https://doi.org/10.1093/bioinformatics/btx352
Research output: Contribution to Journal › Article (Published) -
De novo protein design: How do we expand into the universe of possible protein structures?
(11 pages)
In:
Current opinion in structural biology, vol. 33, pp. 16-26
DOI: https://doi.org/10.1016/j.sbi.2015.05.009
Research output: Contribution to Journal › Review article (Published) -
Modular design of self-assembling peptide-based nanotubes
(9 pages)
In:
Journal of the American Chemical Society, vol. 137, pp. 10554-10562
DOI: https://doi.org/10.1021/jacs.5b03973
Research output: Contribution to Journal › Article (Published) -
Computational design of water-soluble α-helical barrels
(4 pages)
In:
Science, vol. 346, pp. 485-488
DOI: https://doi.org/10.1126/science.1257452
Research output: Contribution to Journal › Article (Published) -
CCBuilder: An interactive web-based tool for building, designing and assessing coiled-coil protein assemblies
(7 pages)
In:
Bioinformatics, vol. 30, pp. 3029-3035
DOI: https://doi.org/10.1093/bioinformatics/btu502
Research output: Contribution to Journal › Article (Published)