Dr Ailith Ewing
Chancellor's Fellow
- MRC Human Genetics Unit
- Cancer Research UK Edinburgh Centre
- Institute of Genetics and Cancer
Contact details
- Email: ailith.ewing@igmm.ed.ac.uk
Background
Ailith Ewing (formerly Pirie) is a Chancellor's Fellow and Group Leader jointly at the MRC Human Genetics Unit and the Cancer Research UK Edinburgh Centre in the Institute of Genetics and Cancer.
Ailith has an MMath (Hons) Statistics degree (First Class) from the University of St Andrews. In 2012, she moved to Cambridge to start her PhD, with Prof. Paul Pharoah, investigating the role of rare germline genetic variation in ovarian cancer susceptibility and survival after diagnosis.
On completion in 2015, she worked as a Medical Statistician in the Clinical Trial Service Unit at the University of Oxford before joining the lab of Prof. Colin Semple as a bioinformatician in September 2016.
In December 2017, Ailith was awarded a UKRI Innovation Fellowship to investigate the mutational landscape of high grade serous ovarian cancer in collaboration with Prof. Charles Gourley, AstraZeneca and the Scottish Genomes Partnership. She was awarded a Chancellor's Fellowship to start her own group in statistical cancer genomics in April 2021.
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Unravelling the tumour genome: the evolutionary and clinical impacts of structural variants in tumourigenesis
In:
Journal of Pathology
DOI: https://doi.org/10.1002/path.5901
Research output: Contribution to Journal › Article (Published) -
Trametinib versus standard of care in patients with recurrent low-grade serous ovarian cancer (GOG 281/LOGS): a randomised, open-label phase 2/3 trial
In:
The Lancet, vol. 399, pp. 541-553
DOI: https://doi.org/10.1016/S0140-6736(21)02175-9
Research output: Contribution to Journal › Article (Published) -
ISGylation drives basal breast tumour progression by promoting EGFR recycling and Akt signalling
In:
Oncogene
DOI: https://doi.org/10.1038/s41388-021-02017-8
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Structural variants at the BRCA1/2 loci are a common source of homologous repair deficiency in high grade serous ovarian carcinoma
In:
Clinical Cancer Research
DOI: https://doi.org/10.1158/1078-0432.CCR-20-4068
Research output: Contribution to Journal › Article (Published) -
Pervasive lesion segregation shapes cancer genome evolution
(6 pages)
In:
Nature, vol. 583, pp. 265–270
DOI: https://doi.org/10.1038/s41586-020-2435-1
Research output: Contribution to Journal › Article (Published) -
Low plasma vitamin D is associated with adverse colorectal cancer survival after surgical resection, independent of systemic inflammatory response
(9 pages)
In:
Gut, vol. 69, pp. 103-111
DOI: https://doi.org/10.1136/gutjnl-2018-317922
Research output: Contribution to Journal › Article (Published) -
Zebrafish MITF-low melanoma subtype models reveal transcriptional subclusters and MITF-independent residual disease
(16 pages)
In:
Cancer Research, vol. 79, pp. 5769-5784
DOI: https://doi.org/10.1158/0008-5472.CAN-19-0037
Research output: Contribution to Journal › Article (Published) -
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
In:
Nature Genetics, vol. 51
DOI: https://doi.org/10.1038/s41588-019-0447-2
Research output: Contribution to Journal › Comment/debate (E-pub ahead of print) -
Breaking point: the genesis and impact of structural variation in tumours
In:
F1000Research
DOI: https://doi.org/10.12688/f1000research.16079.1
Research output: Contribution to Journal › Review article (Published) -
Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer
In:
Nature Genetics, vol. 49, pp. 680-691
DOI: https://doi.org/10.1038/ng.3826
Research output: Contribution to Journal › Article (Published)