Dr Adam Gow

Head of Small Animal Internal Medicine, Senior Lecturer in Small Animal Medicine

Background

Adam graduated from the R(D)SVS, and initially worked in two large small animal hospital practices in Gloucestershire. On returning back to Scotland, three years were then spent in an out-of-hours emergency clinic before joining the R(D)SVS, first as Visiting Clinical Fellow, then Resident in Canine Medicine. Adam became a European Specialist Veterinary Internal Medicine and Royal College of Veterinary Surgeons Diplomat of Small Animal Medicine in 2010. A year was then spent back in first opinion practice in Edinburgh before he then completed a PhD on production of canine liver cells from stem cell sources at the Roslin Institute and R(D)SVS. It is hoped that this research will help development of new drugs for the dog as well as reduce the need for animal testing. Adam is currently head of  small animal internal medicine at the R(D)SVS. Adam’s clinical and research interests include pet-side testing, gastroenterology, liver disease and hepatic encephalopathy.

Qualifications

Doctor of Philosophy (PhD), University of Edinburgh Production of Canine Hepatocytes from Stem Cell Sources Postgraduate Diploma, European College of Veterinary Internal Medicine European Diplomat in Veterinary Internal Medicine Postgraduate Diploma, Royal College of Veterinary Surgeons Diploma in Small Animal Medicine, Fellow of the Higher Education Authority

Responsibilities & affiliations

Head of Small Animal Internal Medicine

Research summary

In vitro production of functional canine hepatocytes from stem cell sources.

Canine liver disease and pathogenesis of hepatic encephalopathy. 

Performance of Pet-side testing

Current research interests

In vitro production of functional canine hepatocytes from stem cell sources Hepatocytes have a crucial role in drug metabolism. The ability to assess drug metabolism in vitro would allow candidate drugs to be screened quickly, cheaply, as well as reducing in vivo testing. Primary hepatocytes do not expand and rapidly lose function in vitro. The ability to differentiate stem cell sources into hepatocytes would have the potential to provide an unlimited supply.   Main themes of research include: Optimising canine primary hepatocyte culture conditions to retain function. Differentiation of canine bone marrow, adipose-derived mesenchymal and induced pluripotent stem cells into hepatocytes.   Clinical Research - Hepatic encephalopathy and canine liver disease Hepatic encephalopathy (HE) is common in the dog, seen as a result of congenital portosystemic shunting and also in acquired liver disease. Although hyperammonaemia is a key driver of this condition, there is increasing recognition that inflammation and disturbed manganese metabolism are important. I am interested in assessing all potential triggers of HE and therefore developing additional therapies to improve the morbidity and mortality of this common condition. Hepatic encephalopathy is a major cause of morbidity and mortality in humans and naturally occurring disease in the dog serves as a useful model for understanding and developing treatments for human medicine.

Research activities

View all 9 activities on Research Explorer

View all 60 publications on Research Explorer

Invited speaker

Recent national/international lecturing activity

    • ECVIM Annual Congress 2019
      • Society for Comparative hepatology expert panel, Case discussions
      • The Role of Systemic inflammation in progression of HE
    • Meeting of experts on congenital porto-systemic shunts Paris
      • Management of Hepatic Encephalopathy
    • Vet Fair Congress 2018
      • Lecture: Fluid therapy
      • Lecture: Leptospirosis
      • Lecture: Anaemia
    • Vet Fair Congress 2017
      • Lecture : Chronic Diarrhoea
      • Lecture: Difficult Diabetes Mellitus
    • ACVIM Denver 2016
      • Lecture: The role of Inflammation in Hepatic Encephalopathy
      • Lecture: Treatment of Hepatic Encephalopathy
      • Round Table discussion: Hepatic Encephalopathy. A Gow, J Lidbury, R. Hill, S. Centre

Papers delivered

Conference Abstracts (oral abstracts in bold)

 

A.G.Gow (2007) Canine African Trypanosomosis in the UK. Small Animal Medicine Society Annual meeting, Birmingham

 

Milne, E.M., Picozzi, K., Gow, A.G., Simpson, J.W. (2007) Haematological changes associated with canine African Trypanosomosis. ECVIM Congress, ECVP

 

A.G. Gow, D.J. Gow, E.J. Hall, D. Langton, K. Papasouliotis (2008) Prevalence of Campylobacter and Salmonella in kittens presenting for initial vaccination to veterinary practitioners in the UK. BSAVA Congress, Birmingham p469

 

D.J. Gow, A.G. Gow, C.Clarke, K. Papasouliotis (2008) Prevalence of endoparasites in kittens presenting for initial vaccination to veterinary practitioners in the UK and owners awareness of potential zoonoses. BSAVA Congress, Birmingham p446

 

Gow, A.G., Gow, D.J., Bell, R., Simpson, J.W., Chandler, M.L., Evans, H., Berry, J.L. Herrtage, M.E., Mellanby, R.J. (2009) Calcium metabolism in dogs with hypoadrenocorticism. BSAVA Congress, Birmingham

 

A.G. Gow, D.J. Gow, R. Bell, M.L.Chandler, H Evans, R.J. Mellanby, J.W. Simpson. (2009) Insulin levels in nine dogs with hypoadrenocorticism and hyperkalaemia. ECVIM Congress, Porto

 

Sheahan D.,  Bell, R., Mellanby R., Gow, A., Friend, E., Heller, J., Bence L., and Eckersall P.D. (2010) An investigation of serum acute phase proteins in nasal disease in dogs. European Colloquium on Acute Phase proteins

 

D.J. Gow, A.G. Gow, D. Spratt, R. Bell, R. Cash, S. Ricketts, J. Archer, M.L.Chandler, H Evans, R.J. Mellanby. (2010) Serum cardiac troponin is increased in dogs with primary immune mediated haemolytic anaemia. BSAVA Congress, Birmingham

 

A.G. Gow, R.W. Else, S. Smith, H. Evans, J. Berry, M. Herrtage, R.J. Mellanby. (2011) Hypovitaminosis D is prevalent in dogs with hypoalbuminaemia and inflammatory bowel disease. BSAVA Congress, Birmingham

 

A.G. Gow, I Battersby, R. Powell, S. Warman, K. Crawford, H. Evans, R. Mellanby. (2011) Insulin concentrations in dogs with chronic hepatic parenchymal disease. BSAVA Congress, Birmingham

 

A.G. Gow, R. Else, S. Smith, A. Duncan, R.J. Mellanby. (2011) Whole blood manganese concentrations are increased in dogs with chronic hepatic parenchymal disease. BSAVA Congress, Birmingham,

 

D.J. Gow, A.G. Gow, K. Simpson, D. Sester, D. Hume. (2011) Production of feline bone marrow macrophages, reagents for studying the CSF-1/CSF1-R system in cats. BSAVA Congress, Birmingham – winner of best poster abstract.

 

A.G. Gow, L. Morrison, D. Hay, D.J. Argyle. (2011) A Study of Canine Hepatic Stem Cells. R(D)SVS Student Research Day, Edinburgh

 

A.G. Gow, L. Morrison, D.J. Argyle. (2012) Primary cell culture and characterisation of a canine hepatocellular carcinoma. World Veterinary Oncology Congress, Paris

 

A.G. Gow, D. Eckersall, R.J. Mellanby. (2012) Serum concentrations of C-reactive protein in dogs with primary hepatitis. World Small Animal Veterinary Association Congress, Birmingham, p570

 

A.G. Gow, A.I. Marques, D.A. Yool, K. Crawford, S. Warman, D. Eckersall, R. Jalan, R.J. Mellanby. (2012) Dogs with spontaneous hepatic encephalopathy have higher serum concentrations of C-reactive protein. World Small Animal Veterinary Association Congress, Birmingham, p474

 

D.J. Gow, A.G. Gow, D.A. Langton, K. Papasouliotis, E.J. Hall. (2012) Detection of attaching and effacing Escherichia coli by multiplex PCR for stx1, stx2, eaeA, ehxA and saa in faecal samples from clinically healthy kittens in the UK. World Small Animal Veterinary Association Congress, Birmingham, p572

 

K. Crawford, S. Warman, A.I. Marques, D.A. Yool, D. Eckersall, R.J. Mellanby, A.G. Gow.(2012)  Serum Haptoglobin concentrations in dogs with liver disease. World Small Animal Veterinary Association Congress, Birmingham, p476

 

A.G. Gow, L.Y. Pang, D. Hay, D.J. Argyle. (2012) Magnetic Assisted Cell Sorting of Hepatic Non-Parenchymal Cells for CD133 Enriches for Hepatic Progenitor Cells. ECVIM-CA Conference, Maastricht, p231

 

A.M.L. Jacinto, R.J. Mellanby, M.L. Chandler, N.X. Bommer, H. Carruthers, L.D. Fairbanks, A.G.Gow. (2012) Urine Concentrations of Purine Metabolites in UK Cavalier King Charles Spaniels. ECVIM-CA Conference, Maastricht, p244

 

A.G. Gow, P. Frowde, C. Elwood, C. Burton, R. Powell, A. Duncan, R.J. Mellanby. (2013) Hypermanganesaemia persists 6 weeks post congenital portosystemic shunt ligation. BSAVA Congress, Birmingham, p602

 

A.G. Gow, A. Duncan, R.J. Mellanby. (2013)Whole blood manganese measurement after prolonged storage at room temperature. BSAVA Congress, Birmingham, p602

 

D.J. Gow, V. Garceau, C. Piridans, A.G. Gow, K. Simpson, D. Gunn-Moore, D. Hume. (2013) In-vitro assessment of cross-species activity of CSF-1 and IL-34 on the feline colony stimulating factor receptor.  BSAVA Congress, Birmingham, p531

 

A.G. Gow, D. Hay, D.J. Argyle. (2013) Characterisation of canine adipose and bone marrow-derived mesenchymal stem cells and hepatocyte differentiation capacity. ECVIM-CA Conference Liverpool

 

A.G. Gow, D. Hay, D.J. Argyle. (2013) Low density lipoprotein (LDL) and acetylated-LDL (Ac-LDL) uptake of primary canine hepatocytes and canine mesenchymal stem cells (MSC). ECVIM-CA Conference Liverpool

 

A.G. Gow, M.S. Tivers, I. Handel, V.J. Lipscomb, R. Jalan, R.J. Mellanby. (2014) Hyperammonaemia and systemic inflammatory response syndrome predicts presence of hepatic encephalopathy in dogs with congenital portosystemic shunts. BSAVA Congress, p516

 

H. Titmarsh, S. Kilpatrick, R.J. Mellanby, A. Gow. (2014) Whole blood thiamine concentrations in dogs with portosystemic shunts and acquired hepathopathies. BSAVA Congress, p516

 

S. Kilpatrick, A.G.Gow, R.D. Foale, S.W. Tappin, H. Carruthers, N. Reed, D.A. Yool, S. Woods, A.I. Marques, R. Jalan, R.J. Mellanby. (2014) Plasma cytokine concentrations in dogs with a congenital portosystemic shunt. . BSAVA Congress, p518

 

S. Kilpatrick, K. Black, A.G. Gow, V. Lipscomb, M.S. Tivers, R.J. Mellanby. (2014) Sodium homeostasis in dogs with liver diseases. . BSAVA Congress, p519

 

H. Titmarsh, S. Kilpatrick, I. Handel, A. Gow, R.J. Mellanby. (2014) Serum cytokine concentrations in dogs with chronic enteropathies. BSAVA Congress, p519

 

C. Brenhay, A. Brown, I. Handel, A.G. Gow (2015) Inter and intra-operator variability in PCV measurement. BSAVA Congress

 

J. Sinclair, D. Gow, A. Brown, A.G. Gow RJ Mellanby (2015) Cardiac troponin immune-mediated haemolytic anaemia  BSAVA Congress

 

J Cartwright, C Breheny, A G Gow, E Pecceu, T Hill (2015) A Case of Spontaneous Portal Vein Gas in an Eleven Month Old West Highland White Terrier. BSAVA Scottish Congress

 

Boag AM, C Breheny, AG Gow (2016) Evaluation of the Effect of Urine Dip Versus

Urine Drip on Multitest Strip Results. ACVIM Congress Denver

 

C. Breheny, A.G. Gow (2017) Does the colour intensity of a blood spot image obtained by smartphone accurately correlate with canine packed cell volume (PCV) BSAVA Congress

 

J. Perez Accino Salgado, A.G. Gow (2017) Reliability of a Smartphone application together with a validated heart rate sensor to measuring measure heart rate in dogs. BSAVA Congress

 

M. Ferreira, R.J. Mellanby, A.G. Gow  (2017) Whole blood manganese concentrations in anaemic dogs with inflammatory bowel disease or confirmed iron-deficiency anaemia. BSAVA Congress

 

Birrell, H., Brown, A., McGuinnes, C., Mellanby, R., Gow, A. & Bell, C (2017) Development of a novel diagnostic assay for the diagnosis of canine immune-mediated thrombocytopenia (IMT) BSAVA Congress

 

M. Ferreira, R.J. Mellanby, A.G. Gow (2017) Comparing visual and automated reading variability of reagent strips.  BSAVA Congress

 

DJ Gow, AG Gow, H Jackson, P Forsyth, DA Hume, T Nuttall (2017) The Role of Macrophage Migration Inhibitory Factor (MIF) in Canine Atopic Dermatitis. ESVD Congress, Switzerland

 

M. Garcia, M. Ferreira, A. Gow (2017) Determining the pH in canine urine: Comparing visual and automated reading variability of urine dipstick analysis within a small animal teaching hospital. ECVIM Congress Malta

 

P. Archontakis, A. Gow (2018) Performance of 2 low-cost pH meters against current pet-side standard. BSAVA

 

C. R. Breheny, J. P. A. Salgado, N. X. Bommer, I. Handel, A. G. Gow (2018) A standard operating procedure reduces inter and intra-operator variation and improves accuracy when measuring packed cell volume. BSAVA

 

C. R. Breheny, R.J. Mellanby, J. Hamilton, A. G. Gow (2018) The effect of ammonia on the canine polymorphonuclear cell oxidative burst BSAVA

 

S. Salavati Schmitz, N. Bommer, R. Mellanby, A. Gow  (2018) Retrospective analysis of dogs with inflammatory protein-losing enteropathy reveals that second-line immunosuppression is only necessary in 1/3 of cases and treatment requirements or outcome cannot be predicted by routine clinicopathological data ECVIM

 

M.F. Ferreira, R.J. Mellanby, A.G. Gow (2018) Serum melatonin concentrations in dogs with congenital portosystemic shunts ECVIM

 

M. Garcia Arce, A. Gow, I. Handel, W. Ngoi, E. Thomas (2018) Red blood cell distribution width (RDW) as a prognostic factor in critically ill dogs EVECCS

 

Pentsou K., Gow A., Duncan J. (2018) Comparison of Fingertip and Handheld Pulse Oximeter Measurement in Anaesthetized Dogs – Preliminary Results WCVA

 

Gow, D.J, Gow A.G, Jackson, H, Nuttall, T, Hume D.A.  Evaluation of serum Interleukin 34 (IL34) in dogs with atopic dermatitis. Accepted as oral presentation at European Society of Veterinary Dermatology (ESVD) annual meeting Sept 2018

C.T. Johnsen; A. Gow; S. Campbell; S. Salavati; N. Bommer; R. Richard. (2019) Investigation of the Efficacy of a Novel Diet in the Management Of Chronic Enteropathies in Dogs. ECVIM Congress Milan

M.F. Ferreira; S. Salavati Schmitz; J.J. Schoenebeck; D.N. Clements; S.M. Campbell; D.E. Gaylor; R.J. Mellanby; A. Gow & M. Salavati (2019) Lactulose Drives a Reversible Reduction and Qualitative Modulation of the Faecal Microbiota Diversity in Healthy Dogs. ECVIM Congress Milan

H.K. Walker; N.X. Bommer; S. Salavati; R.J. Mellanby; A. Gow  (2019) Retrospective Analysis of Cases Tested for Leptospirosis at a University Teaching Hospital. ECVIM Congress Milan.

C.T. Johnsen; T. Schnabel; A. Gow; J. del-Pozo; E. Milne; V. Macklin; C. Fisher; I. Handel; R. Mellanby  (2019) Investigation of the Relationship Between Ionised and Total Calcium in Dogs with Ionised Hypercalcaemia. ECVIM Congress Milan.