Douglas Houston



2015-Present    Senior Lecturer in Computational Biochemistry, University of Edinburgh

2011-2015    Lecturer in Computational Biochemistry, University of Edinburgh

2009-2011    Scientific Program Coordinator, University of Edinburgh

2009    Postdoctoral Fellow, University of Edinburgh

2005-2008    Postdoctoral Fellow, McGill University, Montreal

2001-2005    PhD Student, University of Dundee

2001-2004    CASE Researcher, Cyclacel Pharmaceuticals Inc., Dundee

Undergraduate teaching

Structures and Functions of Proteins (Biochemistry 3rd Year)

Structural Biology (Biochemistry Hons)

Novel Approaches (Biotechnology Hons)

Enzymology and Biological Production (Biotechnology Hons)

Postgraduate teaching

Next Generation Drug Discovery ODL MSc

Drug Discovery and Translational Biology MSc

Biotechnology MSc

Biochemistry MSc

Research summary

Virtual screening technology development

Methods development; improving the speed, efficiency and hit rates of ligand- and structure-based virtual screening techniques.

Design of E3 ligase protein-protein interaction disruptors through synthetic biology

Computer Aided Design of foldamer inhibitors of high-priority cancer targets. In collaboration with Julien Michel (School of Chemistry) and Ted Hupp (Edinburgh Cancer Research UK Centre).

Discovery and design of anthelmintics

Computer Aided Discovery of inhibitors of the essential cuticle shedding phase of the nematode parasite lifecycle. In collaboration with Malcolm Walkinshaw (Institute of Structural and Molecular Biology) and Anthony Page (University of Glasgow).

Probing the roles and mechanisms of AAA+ enzymes through chemical biology

Virtual screening and molecular modelling of AAA+ enzymes to identify small molecule modulators of complex assembly. In collaboration with Nicholas Westwood (University of St Andrews) and Ted Hupp.

Keywords: Virtual screening, molecular modelling, structural biology, drug discovery, cheminformatics, X-ray crystallography, molecular dynamics, protein-ligand binding, noncovalent interactions