Douglas Houston



2016-Present    Senior Lecturer in Computational Biochemistry, University of Edinburgh

2011-2016    Lecturer in Computational Biochemistry, University of Edinburgh

2009-2011    Scientific Program Coordinator, University of Edinburgh

2009    Postdoctoral Fellow, University of Edinburgh

2005-2008    Postdoctoral Fellow, McGill University, Montreal

2001-2005    PhD Student, University of Dundee

2001-2004    CASE Researcher, Cyclacel Pharmaceuticals Inc., Dundee

Undergraduate teaching

Structures and Functions of Proteins (Biochemistry 3rd Year)

Structural Biology (Biochemistry Hons)

Biochemical Techniques (Biochemistry Hons)

Novel Approaches (Biotechnology Hons)

Enzymology and Biological Production (Biotechnology Hons)

Postgraduate teaching

Industry and Entrepreneurship (Biotechnology MSc)

Introduction to Python Programming for Data Science (Data Science and Technology Innovation MSc / Drug Discovery and Translational Biology MSc)

Programming for the Life Sciences (Biochemistry MSc)

Biochemistry A (Biochemistry MSc)

Biochemistry B (Biochemistry MSc)

Open to PhD supervision enquiries?


Research summary

Virtual screening technology development

Methods development; improving the speed, efficiency and hit rates of ligand- and structure-based virtual screening techniques. In collaboration with Malcolm Walkinshaw (IQB3).


Design of E3 ligase protein-protein interaction disruptors through synthetic biology

Computer Aided Design of foldamer inhibitors of high-priority cancer targets. In collaboration with Ted Hupp (Edinburgh Cancer Research UK Centre).


Discovery and design of anthelmintics

Computer Aided Discovery of inhibitors of the essential cuticle shedding phase of the nematode parasite lifecycle. In collaboration with Malcolm Walkinshaw (IQB3) and Anthony Page (University of Glasgow).


Probing the roles and mechanisms of AAA+ enzymes through chemical biology

Virtual screening and molecular modelling of AAA+ enzymes to identify small molecule modulators of complex assembly. In collaboration with Nicholas Westwood (University of St Andrews) and Ted Hupp.


Keywords: Virtual screening, molecular modelling, structural biology, drug discovery, cheminformatics, X-ray crystallography, molecular dynamics, protein-ligand binding, noncovalent interactions.


Knowledge exchange

Houston, D. (2019, November 28). The utility of consensus approaches in virtual drug discovery [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 29, 2019, from


Research activities

View all 2 activities on Research Explorer

View all 44 publications on Research Explorer