Deborah Charlesworth

Contact details
- Tel: +44 (0)131 650 5751
- Email: deborah.charlesworth@ed.ac.uk
Address
- Street
-
Institute of Evolutionary Biology, University of Edinburgh,
Ashworth Lab., room G.61A - City
- Charlotte Auerbach Road, King's Buildings, Edinburgh
- Post code
- EH9 3FL
Background
1968 PhD (Genetics) Cambridge University
1968 - 69 MRC Junior Research Fellow, Cambridge University
1969-71 Postdoctoral fellow, University of Chicago
1971-74 Honorary Research Fellow, Liverpool University
1974-84 Temporary Lecturer, University of Sussex
1977-78 Visiting Scientist, NIEHS (NIH) North Carolina
1984-88 Research Associate, University of Chicago
1988-92 Assistant Professor, University of Chicago
1992-1997 Professor, University of Chicago
1997-2002 NERC Senior Research Fellow, University of Edinburgh
1997-present Professorial Research Fellow, University of Edinburgh
2005 Fellow of the Royal Society
Open to PhD supervision enquiries?
No
Research summary
Evolutionary and population genetics, particularly topics in the general area of the evolution of breeding systems and sex chromosomes.
Current research interests
The genetics and evolution of the Y chromosome in the guppy (a fish, Poecilia reticulata).Past research interests
Self-incompatibility, the evolution of Y-linked genes in the white campion, Silene latifolia.Research activities
- Why are sex-determining genes located within non-recombining genome regions?
- The molecular basis and evolution of sexual dimorphism - virtual to
- Botany 2020
- Invited lecturer at graduate student retreat, University of Zürich
- ERC Advanced grant panel reviewer 2019
- Molecular Biology and Evolution (Journal)
- European Molecular Biology Organisation (EMBO) (External organisation)
- Genetics (Journal) to
- Edinburgh International Science Festival
- Conférence Universitaire de Suisse Occidentale
- Munich Graduate School for Evolution, Ecology, and Systematics
- Ecole Normale Superieure to
- BBSRC summer school on Molecular Evolution and Diversity to
- BMC Genetics (Journal)
- Evolution: International Journal of Organic Evolution (Journal)
- Current Biology (Journal)
- PLoS.Genet. (Journal)
- PLoS Biology (Journal)
- Nature (Journal)
- Genetics (Journal)
Current project grants
ERC Advanced grant: Evolutionary genetics of guppy sex chromosomes (695225)
Past project grants
NOT LISTED
-
Recurrent neo-sex chromosome evolution in kiwifruit
(10 pages)
In:
Nature Plants, pp. 393–402
DOI: https://doi.org/10.1038/s41477-023-01361-9
Research output: Contribution to Journal › Article (Published) -
Why and how do Y chromosome stop recombining?
(5 pages)
In:
Journal of Evolutionary Biology
DOI: https://doi.org/10.1111/jeb.14137
Research output: Contribution to Journal › Comment/debate (E-pub ahead of print) -
Independent evolution of sex chromosomes and male pregnancy-related genes in two seahorse species
(19 pages)
In:
Molecular Biology and Evolution, vol. 40
DOI: https://doi.org/10.1093/molbev/msac279
Research output: Contribution to Journal › Article (Published) -
Partial sex linkage and linkage disequilibrium on the guppy sex chromosome
(14 pages)
In:
Molecular Ecology, vol. 31, pp. 5524-5537
DOI: https://doi.org/10.1111/mec.16674
Research output: Contribution to Journal › Article (Published) -
Primrose homostyles: A classic case of possible balancing selection re‐visited
(3 pages)
In:
Molecular Ecology
DOI: https://doi.org/10.1111/mec.16746
Research output: Contribution to Journal › Article (E-pub ahead of print) -
The mysterious sex chromosomes of haploid plants
(10 pages)
In:
Heredity, vol. 129, pp. 17-21
DOI: https://doi.org/10.1038/s41437-022-00524-2
Research output: Contribution to Journal › Article (Published) -
Evolution of sexual systems, sex chromosomes and sex-linked gene transcription in flatworms and roundworms
(15 pages)
In:
Nature Communications, vol. 13
DOI: https://doi.org/10.1038/s41467-022-30578-z
Research output: Contribution to Journal › Article (Published) -
Some thoughts about the words we use for thinking about sex chromosome evolution
In:
Philosophical Transactions of the Royal Society B: Biological Sciences, vol. 377
DOI: https://doi.org/10.1098/rstb.2021.0314
Research output: Contribution to Journal › Review article (Published) -
The timing of genetic degeneration of sex chromosomes
(11 pages)
In:
Philosophical Transactions of the Royal Society B: Biological Sciences, vol. 376
DOI: https://doi.org/10.1098/rstb.2020.0093
Research output: Contribution to Journal › Review article (Published) -
How did the guppy Y chromosome evolve?
(34 pages)
In:
PLoS Genetics, vol. 17
DOI: https://doi.org/10.1371/journal.pgen.1009704
Research output: Contribution to Journal › Article (Published) -
Evolution: Shape-shifting vole sex determination and sex chromosomes
(3 pages)
In:
Current Biology, vol. 31, pp. PR967-R969
DOI: https://doi.org/10.1016/j.cub.2021.06.045
Research output: Contribution to Journal › Editorial (Published) -
PromethION sequencing and assembly of the genome of Micropoecilia picta, a fish with a highly Degenerated Y chromosome
(11 pages)
In:
Genome Biology and Evolution, vol. 13
DOI: https://doi.org/10.1093/gbe/evab171
Research output: Contribution to Journal › Article (E-pub ahead of print) -
The puzzling guppy Y chromosome
In:
Nature Reviews Genetics
DOI: https://doi.org/10.1038/s41576-021-00369-1
Research output: Contribution to Journal › Review article (Published) -
Chromosome‐scale assembly of the genome of Salix dunnii reveals a male‐heterogametic sex determination system on chromosome 7
(45 pages)
In:
Molecular Ecology Resources
DOI: https://doi.org/10.1111/1755-0998.13362
Research output: Contribution to Journal › Article (Published) -
When and how do sex-linked regions become sex chromosomes?
(12 pages)
In:
Evolution: International Journal of Organic Evolution, vol. 75, pp. 569-581
DOI: https://doi.org/10.1111/evo.14196
Research output: Contribution to Journal › Special issue (E-pub ahead of print) -
Using GC content to compare recombination patterns on the sex chromosomes and autosomes of the guppy, Poecilia reticulata, and its close outgroup species
(13 pages)
In:
Molecular Biology and Evolution, vol. 37, pp. 3550–3562
DOI: https://doi.org/10.1093/molbev/msaa187
Research output: Contribution to Journal › Article (Published) -
Evidences for a role of two Y-specific genes in sex determination in Populus deltoides
In:
Nature Communications, vol. 11
DOI: https://doi.org/10.1038/s41467-020-19559-2
Research output: Contribution to Journal › Article (Published) -
Improved reference genome uncovers novel sex-linked regions in the Guppy (Poecilia reticulata)
(17 pages)
In:
Genome Biology and Evolution, vol. 12, pp. 1789-1805
DOI: https://doi.org/10.1093/gbe/evaa187
Research output: Contribution to Journal › Article (Published) -
Locating the sex determining region of linkage group 12 of guppy (Poecilia reticulata)
(11 pages)
In:
G3: Genes | Genomes | Genetics, vol. 10, pp. 3639–3649
DOI: https://doi.org/10.1534/g3.120.401573
Research output: Contribution to Journal › Article (Published) -
Young sex chromosomes in plants and animals
In:
New Phytologist, vol. 224
DOI: https://doi.org/10.1111/nph.16002
Research output: Contribution to Journal › Review article (E-pub ahead of print)
Invited speaker
Invited speaker in Crafoord Prize symposium, Stockholm, May 2015
Invited speaker in symposium on sex chromosomes, annual SMBE Conference, Vienna 2015
Invited speaker in “BarrettFest” symposium honouring SCH Barrett, University of Toronto, September 2018
Participant
Population Genetics Group annual meeting (every year)