Dawn Livingstone
Academic Track Lecturer
- Centre for Cardiovascular Science
Contact details
- Tel: 0131 242 6742
- Email: Dawn.Livingstone@ed.ac.uk
Address
- Street
-
Queens Medical Research Institute
Edinburgh Bioquarter
47 Little France Crescent - City
- Edinburgh
- Post code
- EH16 4TJ
Research summary
Steroid hormones have potent effects on fuel metabolism, body fat distribution and behaviour. My research focusses on the ways in which these actions are “fine-tuned” by pre-receptor metabolism within target tissues, and how this can alter susceptibility to the development of obesity and diabetes. Through these studies we have also identified a steroid hormone metabolite that has potential for development as a selective glucocorticoid receptor modulator for use in the treatment of inflammation. http://www.ed.ac.uk/integrative-physiology/staff-profiles/research-group...
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A role for steroid 5 alpha-reductase 1 in vascular remodeling during endometrial decidualization
In:
Frontiers in Endocrinology, vol. 13
DOI: https://doi.org/10.3389/fendo.2022.1027164
Research output: Contribution to Journal › Article (Published) -
High salt intake activates the hypothalamic-pituitary-adrenal axis, amplifies the stress response, and alters tissue glucocorticoid exposure in mice
In:
Cardiovascular Research
DOI: https://doi.org/10.1093/cvr/cvac160
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Comparison of mechanisms of angiostasis caused by the anti-inflammatory steroid 5α-tetrahydrocorticosterone versus conventional glucocorticoids
In:
European Journal of Pharmacology, pp. 175111
DOI: https://doi.org/10.1016/j.ejphar.2022.175111
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Endothelin-1 mediates the systemic and renal hemodynamic effects of GPR81 activation
In:
Hypertension
DOI: https://doi.org/10.1161/HYPERTENSIONAHA.119.14308
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Role of hepatic glucocorticoid receptor in metabolism in models of 5αR1 Deficiency in Male Mice
In:
Endocrinology
DOI: https://doi.org/10.1210/en.2019-00236
Research output: Contribution to Journal › Article (Published) -
Species-specific regulation of angiogenesis by glucocorticoids reveals contrasting effects on inflammatory and angiogenic pathways
In:
PLoS ONE, vol. 13
DOI: https://doi.org/10.1371/journal.pone.0192746
Research output: Contribution to Journal › Article (Published) -
Quantification of 11β-hydroxysteroid dehydrogenase 1 kinetics and pharmacodynamic effects of inhibitors in brain using mass spectrometry imaging and stable-isotope tracers in mice
In:
Biochemical Pharmacology, vol. 148, pp. 88-99
DOI: https://doi.org/10.1016/j.bcp.2017.12.013
Research output: Contribution to Journal › Article (Published) -
11β-HSD2 SUMOylation Modulates Cortisol-induced Mineralocorticoid Receptor Nuclear Translocation Independently of Effects on Transactivation
In:
Endocrinology
DOI: https://doi.org/10.1210/en.2017-00440
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Safer topical treatment for inflammation using 5α-tetrahydrocorticosterone in mouse models
In:
Biochemical Pharmacology, vol. 129, pp. 73–84
DOI: https://doi.org/10.1016/j.bcp.2017.01.008
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Metabolic dysfunction in female mice with disruption of 5α-reductase 1
In:
Journal of Endocrinology, vol. 232, pp. 29-36
DOI: https://doi.org/10.1530/JOE-16-0125
Research output: Contribution to Journal › Article (Published) -
Spatial Localization and Quantitation of Androgens in Mouse Testis by Mass Spectrometry Imaging
In:
Analytical Chemistry, vol. 88
DOI: https://doi.org/10.1021/acs.analchem.6b02242
Research output: Contribution to Journal › Article (E-pub ahead of print) -
ABCC1 confers tissue-specific sensitivity to cortisol versus corticosterone: a rationale for safer glucocorticoid replacement therapy
(12 pages)
In:
Science Translational Medicine, vol. 8
DOI: https://doi.org/10.1126/scitranslmed.aaf9074
Research output: Contribution to Journal › Article (Published) -
Metformin increases cortisol regeneration by 11βHSD1 in obese men with and without type 2 diabetes mellitus
In:
The Journal of Clinical Endocrinology & Metabolism (JCEM), pp. jc20162069
DOI: https://doi.org/10.1210/jc.2016-2069
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Aromatase Inhibition Reduces Insulin Sensitivity in Healthy Men
In:
The Journal of Clinical Endocrinology & Metabolism (JCEM), pp. jc.2015-4146
DOI: https://doi.org/10.1210/jc.2015-4146
Research output: Contribution to Journal › Article (E-pub ahead of print) -
5 alpha-Reductase Type 1 Deficiency or Inhibition Predisposes to Insulin Resistance, Hepatic Steatosis, and Liver Fibrosis in Rodents
(12 pages)
In:
Diabetes, vol. 64, pp. 447-458
DOI: https://doi.org/10.2337/db14-0249
Research output: Contribution to Journal › Article (Published) -
5α-Reductase Type 1 Modulates Insulin Sensitivity in Men
(10 pages)
In:
The Journal of Clinical Endocrinology & Metabolism (JCEM), vol. 99, pp. E1397-E1406
DOI: https://doi.org/10.1210/jc.2014-1395
Research output: Contribution to Journal › Article (Published) -
Relative adrenal insufficiency in mice deficient in 5α-reductase 1
(10 pages)
In:
Journal of Endocrinology, vol. 222, pp. 257-266
DOI: https://doi.org/10.1530/JOE-13-0563
Research output: Contribution to Journal › Article (Published) -
Physiological roles of glucocorticoids during early embryonic development of the zebrafish (Danio rerio)
(12 pages)
In:
The Journal of Physiology, vol. 591, pp. 6209-6220
DOI: https://doi.org/10.1113/jphysiol.2013.256826
Research output: Contribution to Journal › Article (Published) -
11β-hydroxysteroid dehydrogenase type 1 deficiency in bone marrow-derived cells reduces atherosclerosis
(13 pages)
In:
The FASEB Journal, vol. 27, pp. 1519-1531
DOI: https://doi.org/10.1096/fj.12-219105
Research output: Contribution to Journal › Article (Published) -
5α-Reductase type 1 inhibition or deficiency causes weight gain and insulin resistance in mice and men
Research output: › Conference contribution (Published)