Dr Christopher Boyd
- Centre for Genomic and Experimental Medicine
- MRC Institute of Genetics and Molecular Medicine
Contact details
- Email: Chris.Boyd@ed.ac.uk
Address
- Street
-
Centre for Genomic & Experimental Medicine MRC Institute of Genetics & Molecular Medicine University of Edinburgh Western General Hospital Crewe Road South
- City
- Edinburgh
- Post code
- EH4 2XU
Background
I'm a scientist working in the Medical Genetics Section of the Centre for Genomic and Experimental Medicine. My background is in prokaryotic molecular biology, with a particular interest in plasmids. Over the years this has evolved into a career in human gene therapy, a research field that impinges on all aspects of biology. I lead the section's cystic fibrosis gene therapy group, which forms part of the UK CF Gene Therapy Consortium (www.cfgenetherapy.org.uk), a collaboration between Imperial College, and the universities of Edinburgh and Oxford. The Consortium has completed a major Phase 2b clinical trial of non-viral gene therapy for CF: Scottish patients attended the Western General Hospital arm of the study. I am a member of the Consortium's strategy group.
My primary research interest is in the pre-clinical development of gene therapy, with a focus on vectorology, though more broadly I am interested in many aspects of genomic engineering.
My principal affiliation is to CGEM within the IGMM, but I also have research links to the Roslin Institute, working closely with Gerry McLachlan and David Collie, and am affiliated to the Centre for Inflammation Research. In addition, I am developing a research collaboration on gene therapy for Primary Ciliary Dyskinesia with Pleasantine Mill and her group in the MRC HGU
-
Progress in Respiratory Gene Therapy
In:
Human Gene Therapy, vol. 33, pp. 893-912
DOI: https://doi.org/10.1089/hum.2022.172
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Preparation for a first-in-man lentivirus trial in patients with cystic fibrosis
In:
Thorax, vol. 72, pp. 137-147
DOI: https://doi.org/10.1136/thoraxjnl-2016-208406
Research output: Contribution to Journal › Article (Published) -
Genetic medicines for CF: Hype versus reality
In:
Pediatric Pulmonology, vol. 51, pp. S5-S17
DOI: https://doi.org/10.1002/ppul.v51.S44
Research output: Contribution to Journal › Review article (Published) -
A randomised, double-blind, placebo-controlled trial of repeated nebulisation of non-viral cystic fibrosis transmembrane conductance regulator (CFTR) gene therapy in patients with cystic fibrosis
(240 pages)
DOI: https://doi.org/10.3310/eme03050
Research output: › Commissioned report (Published) -
A Phase I/IIa Safety and Efficacy Study of Nebulized Liposome-mediated Gene Therapy for Cystic Fibrosis Supports a Multidose Trial
(4 pages)
In:
American Journal of Respiratory and Critical Care Medicine, vol. 192, pp. 1389-92
DOI: https://doi.org/10.1164/rccm.201506-1193LE
Research output: Contribution to Journal › Article (Published)