Brian Walker | The University of Edinburgh

Pro Vice Chancellor for Research Strategy & Resources and Chair of Medicine at Newcastle University

Centre for Cardiovascular Science

Email: b.r.walker@ed.ac.uk

Publications

Low dose dexamethasone as treatment for women with heavy menstrual bleeding: a response-adaptive randomised placebo-controlled dose-finding parallel group trial (DexFEM) 2 Jul 2021 In: EBioMedicine, vol. 69
DOI: https://doi.org/10.1016/j.ebiom.2021.103434
Research output: Contribution to Journal › Article (Published)
Carbonyl reductase 1 amplifies glucocorticoid action in adipose tissue and impairs glucose tolerance in lean mice. 27 Mar 2021 In: Molecular Metabolism
DOI: https://doi.org/10.1016/j.molmet.2021.101225
Research output: Contribution to Journal › Article (E-pub ahead of print)
Long-term stability of cortisol production and metabolism throughout adolescence: longitudinal twin study 25 Mar 2020 In: Twin Research and Human Genetics
DOI: https://doi.org/10.1017/thg.2020.6
Research output: Contribution to Journal › Article (Published)
Heritability of cortisol production and metabolism throughout adolescence: a twin study 14 Oct 2019 In: Journal of Clinical Endocrinology & Metabolism
DOI: https://doi.org/10.1210/clinem/dgz016
Research output: Contribution to Journal › Article (Published)
Incidence of type 2 diabetes mellitus in men receiving steroid 5α-reductase inhibitors: population based cohort study (11 pages) 10 Apr 2019 In: British Medical Journal (BMJ), vol. 365
DOI: https://doi.org/10.1136/bmj.l1204
Research output: Contribution to Journal › Article (Published)
Higher Insulin Resistance and Adiposity in Postmenopausal Women With Breast Cancer Treated With Aromatase Inhibitors 28 Mar 2019 In: Journal of Clinical Endocrinology & Metabolism, vol. 104, pp. 3670–3678
DOI: https://doi.org/10.1210/jc.2018-02339
Research output: Contribution to Journal › Article (E-pub ahead of print)
11Beta‐hydroxysteroid dehydrogenase‐1 deficiency or inhibition enhances hepatic myofibroblast activation in murine liver fibrosis (15 pages) 21 May 2018 In: Hepatology, vol. 67, pp. 2167-2181
DOI: https://doi.org/10.1002/hep.29734
Research output: Contribution to Journal › Article (Published)
Species-specific regulation of angiogenesis by glucocorticoids reveals contrasting effects on inflammatory and angiogenic pathways 15 Feb 2018 In: PLoS ONE, vol. 13
DOI: https://doi.org/10.1371/journal.pone.0192746
Research output: Contribution to Journal › Article (Published)
Quantification of 11β-hydroxysteroid dehydrogenase 1 kinetics and pharmacodynamic effects of inhibitors in brain using mass spectrometry imaging and stable-isotope tracers in mice 1 Feb 2018 In: Biochemical Pharmacology, vol. 148, pp. 88-99
DOI: https://doi.org/10.1016/j.bcp.2017.12.013
Research output: Contribution to Journal › Article (Published)
Plasma metabolomic profile varies with glucocorticoid dose in patients with congenital adrenal hyperplasia 6 Dec 2017 In: Scientific Reports, vol. 7, pp. 17092
DOI: https://doi.org/10.1038/s41598-017-17220-5
Research output: Contribution to Journal › Article (Published)
Development of a Bayesian response-adaptive trial design for the Dexamethasone for Excessive Menstruation study (19 pages) 1 Dec 2017 In: Statistical Methods in Medical Research, vol. 26, pp. 2681-2699
DOI: https://doi.org/10.1177/0962280215606155
Research output: Contribution to Journal › Article (Published)
Gas chromatography tandem mass spectrometry offers advantages for urinary steroids analysis Dec 2017 In: Analytical Biochemistry, vol. 538
DOI: https://doi.org/10.1016/j.ab.2017.09.002
Research output: Contribution to Journal › Article (Published)
Hair cortisol in twins: Heritability and genetic overlap with psychological variables and stress-system genes 10 Nov 2017 In: Scientific Reports
DOI: https://doi.org/10.1038/s41598-017-11852-3
Research output: Contribution to Journal › Article (E-pub ahead of print)
The low single nucleotide polymorphism heritability of plasma and saliva cortisol levels (8 pages) Nov 2017 In: Psychoneuroendocrinology, vol. 85, pp. 88-95
DOI: https://doi.org/10.1016/j.psyneuen.2017.08.011
Research output: Contribution to Journal › Article (Published)
Acute interaction between hydrocortisone and insulin alters the plasma metabolome in humans 13 Sep 2017 In: Scientific Reports
DOI: https://doi.org/10.1038/s41598-017-10200-9
Research output: Contribution to Journal › Article (E-pub ahead of print)
Carbonyl reductase 1 catalyzes 20β-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity 6 Sep 2017 In: Scientific Reports, vol. 7
DOI: https://doi.org/10.1038/s41598-017-10410-1
Research output: Contribution to Journal › Article (Published)
Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits 1 Jun 2017 In: American Journal of Human Genetics, vol. 100, pp. 865-884
DOI: https://doi.org/10.1016/j.ajhg.2017.04.014
Research output: Contribution to Journal › Article (Published)
11β-HSD1 suppresses cardiac fibroblast CXCL2, CXCL5 and neutrophil recruitment to the heart post MI (13 pages) 1 Jun 2017 In: Journal of Endocrinology, vol. 233, pp. 315-327
DOI: https://doi.org/10.1530/JOE-16-0501
Research output: Contribution to Journal › Article (Published)
Selection and early clinical evaluation of the brain-penetrant 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor UE2343 (Xanamem™) Mar 2017 In: British Journal of Pharmacology
DOI: https://doi.org/10.1111/bph.13699
Research output: Contribution to Journal › Article (Published)
Acute physiological effects of glucocorticoids on fuel metabolism in humans are permissive but not direct 8 Feb 2017 In: Diabetes, Obesity and Metabolism
DOI: https://doi.org/10.1111/dom.12899
Research output: Contribution to Journal › Article (E-pub ahead of print)

View all 254 publications on Research Explorer

This article was published on 27 Mar, 2022