Brian Walker
Pro Vice Chancellor for Research Strategy & Resources and Chair of Medicine at Newcastle University
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The ATP-binding cassette proteins ABCB1 and ABCC1 as modulators of glucocorticoid action
In:
Nature reviews endocrinology
DOI: https://doi.org/10.1038/s41574-022-00745-9
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Non-invasive in vivo assessment of 11β-hydroxysteroid dehydrogenase type 1 activity by 19 F-magnetic resonance spectroscopy
In:
Scientific Reports
DOI: https://doi.org/10.1038/s41598-022-18740-5
Research output: Contribution to Journal › Article (Published) -
Comparison of mechanisms of angiostasis caused by the anti-inflammatory steroid 5α-tetrahydrocorticosterone versus conventional glucocorticoids
In:
European Journal of Pharmacology, pp. 175111
DOI: https://doi.org/10.1016/j.ejphar.2022.175111
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Corticotroph isolation from Pomc-eGFP mice reveals sustained transcriptional dysregulation characterising a mouse model of glucocorticoid-induced suppression of the Hypothalamus-Pituitary-Adrenal axis
In:
Journal of Neuroendocrinology
DOI: https://doi.org/10.1111/jne.13165
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Low dose dexamethasone as treatment for women with heavy menstrual bleeding: a response-adaptive randomised placebo-controlled dose-finding parallel group trial (DexFEM)
In:
EBioMedicine, vol. 69
DOI: https://doi.org/10.1016/j.ebiom.2021.103434
Research output: Contribution to Journal › Article (Published) -
Carbonyl reductase 1 amplifies glucocorticoid action in adipose tissue and impairs glucose tolerance in lean mice.
In:
Molecular Metabolism
DOI: https://doi.org/10.1016/j.molmet.2021.101225
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Long-term stability of cortisol production and metabolism throughout adolescence: longitudinal twin study
In:
Twin Research and Human Genetics
DOI: https://doi.org/10.1017/thg.2020.6
Research output: Contribution to Journal › Article (Published) -
Heritability of cortisol production and metabolism throughout adolescence: a twin study
In:
The Journal of Clinical Endocrinology & Metabolism (JCEM)
DOI: https://doi.org/10.1210/clinem/dgz016
Research output: Contribution to Journal › Article (Published) -
Incidence of type 2 diabetes mellitus in men receiving steroid 5α-reductase inhibitors: population based cohort study
(11 pages)
In:
British Medical Journal (BMJ), vol. 365
DOI: https://doi.org/10.1136/bmj.l1204
Research output: Contribution to Journal › Article (Published) -
Higher Insulin Resistance and Adiposity in Postmenopausal Women With Breast Cancer Treated With Aromatase Inhibitors
In:
The Journal of Clinical Endocrinology & Metabolism (JCEM), vol. 104, pp. 3670–3678
DOI: https://doi.org/10.1210/jc.2018-02339
Research output: Contribution to Journal › Article (E-pub ahead of print) -
11Beta‐hydroxysteroid dehydrogenase‐1 deficiency or inhibition enhances hepatic myofibroblast activation in murine liver fibrosis
(15 pages)
In:
Hepatology, vol. 67, pp. 2167-2181
DOI: https://doi.org/10.1002/hep.29734
Research output: Contribution to Journal › Article (Published) -
Species-specific regulation of angiogenesis by glucocorticoids reveals contrasting effects on inflammatory and angiogenic pathways
In:
PLoS ONE, vol. 13
DOI: https://doi.org/10.1371/journal.pone.0192746
Research output: Contribution to Journal › Article (Published) -
Quantification of 11β-hydroxysteroid dehydrogenase 1 kinetics and pharmacodynamic effects of inhibitors in brain using mass spectrometry imaging and stable-isotope tracers in mice
In:
Biochemical Pharmacology, vol. 148, pp. 88-99
DOI: https://doi.org/10.1016/j.bcp.2017.12.013
Research output: Contribution to Journal › Article (Published) -
Plasma metabolomic profile varies with glucocorticoid dose in patients with congenital adrenal hyperplasia
In:
Scientific Reports, vol. 7, pp. 17092
DOI: https://doi.org/10.1038/s41598-017-17220-5
Research output: Contribution to Journal › Article (Published) -
Development of a Bayesian response-adaptive trial design for the Dexamethasone for Excessive Menstruation study
(19 pages)
In:
Statistical Methods in Medical Research, vol. 26, pp. 2681-2699
DOI: https://doi.org/10.1177/0962280215606155
Research output: Contribution to Journal › Article (Published) -
Gas chromatography tandem mass spectrometry offers advantages for urinary steroids analysis
In:
Analytical Biochemistry, vol. 538
DOI: https://doi.org/10.1016/j.ab.2017.09.002
Research output: Contribution to Journal › Article (Published) -
Hair cortisol in twins: Heritability and genetic overlap with psychological variables and stress-system genes
In:
Scientific Reports
DOI: https://doi.org/10.1038/s41598-017-11852-3
Research output: Contribution to Journal › Article (E-pub ahead of print) -
The low single nucleotide polymorphism heritability of plasma and saliva cortisol levels
(8 pages)
In:
Psychoneuroendocrinology, vol. 85, pp. 88-95
DOI: https://doi.org/10.1016/j.psyneuen.2017.08.011
Research output: Contribution to Journal › Article (Published) -
Acute interaction between hydrocortisone and insulin alters the plasma metabolome in humans
In:
Scientific Reports
DOI: https://doi.org/10.1038/s41598-017-10200-9
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Carbonyl reductase 1 catalyzes 20β-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity
In:
Scientific Reports, vol. 7
DOI: https://doi.org/10.1038/s41598-017-10410-1
Research output: Contribution to Journal › Article (Published)