Prof Brendan Corcoran (MVB, DipPharm, PhD, MRCVS)
Personal Chair of Veterinary Cardiopulmonary Medicine
Contact details
Address
- Street
-
The Royal (Dick) School of Veterinary Studies and the Roslin Institute
Easter Bush Campus
Midlothian - City
- Post code
- EH25 9RG
Availability
Willingness to take Ph.D. students: Yes
Background
After several years in private practice in New York and in London, I joined the R(D)SVS as a small animal clinician in 1986 and since then developed an interest in cardiology and respiratory medicine of dogs and cats, and have been Head of the Cardiopulmonary Service, Head of the Clinical Division and Director of the Hospital for Small Animals. This clinical career was interrupted by a three year Wellcome Leave Fellowship in respiratory physiology. My research interests had been initially in respiratory medicine and physiology but more latterly has concentrated on mitral valve disease at all levels from clinical features to molecular mechanisms.
Area of Expertise
Research Expertise: Veterinary Medicine, Professional Governance, Veterinary Clinical Research, Internationalisation in a University context
Qualifications
Bachelors in Veterinary Medicine, University College Dublin Doctor of Philosophy (PhD), University of Edinburgh
Professional Qualifications
Member of the Royal College of Veterinary Surgeons, MRCVS
Responsibilities & affiliations
Deputy Head of School
University Dean International North America
Research summary
Mitral valve disease in dogs, tissue engineered solutions to sourcing valve tissue for research.
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TGF-β induced PI3K/AKT/mTOR pathway controls myofibroblast differentiation and secretory phenotype of valvular interstitial cells through the modulation of cellular senescence in a naturally occurring in vitro canine model of myxomatous mitral valve disease
(23 pages)
In:
Cell proliferation, pp. 1-23
DOI: https://doi.org/10.1111/cpr.13435
Research output: Contribution to Journal › Article (E-pub ahead of print) -
p53 regulates mitochondrial dynamics in vascular smooth muscle cell calcification.
In:
International Journal of Molecular Sciences, vol. 24
DOI: https://doi.org/10.3390/ijms24021643
Research output: Contribution to Journal › Article (Published) -
Metformin protects against vascular calcification through the selective degradation of Runx2 by the p62 autophagy receptor
(14 pages)
In:
Journal of Cellular Physiology, vol. 237, pp. 4303-4316
DOI: https://doi.org/10.1002/jcp.30887
Research output: Contribution to Journal › Article (E-pub ahead of print) -
The Role of Transforming Growth Factor-β Signaling in Myxomatous Mitral Valve Degeneration
In:
Frontiers in Cardiovascular Medicine, vol. 9
DOI: https://doi.org/10.3389/fcvm.2022.872288
Research output: Contribution to Journal › Review article (Published) -
Topographical distribution and radiographic pattern of lung lesions in canine eosinophilic bronchopneumopathy
In:
Journal of Small Animal Practice, vol. 62, pp. 655-661
DOI: https://doi.org/10.1111/jsap.13319
Research output: Contribution to Journal › Article (Published) -
Comparative transcriptomic profiling of myxomatous mitral valve disease in the Cavalier King Charles Spaniel
In:
BMC Veterinary Research
DOI: https://doi.org/10.1186/s12917-020-02542-w
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Expression of calcification and extracellular matrix genes in the cardiovascular system of the healthy domestic sheep (Ovis aries).
In:
Frontiers in genetics, vol. 11
DOI: https://doi.org/10.3389/fgene.2020.00919
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Glucocorticoid metabolism and the action of 11 beta-hydroxysteroid dehydrogenase 2 in canine congestive heart failure
In:
The Veterinary Journal
DOI: https://doi.org/10.1016/j.tvjl.2020.105456
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Disease severity-associated gene expression in canine myxomatous mitral valve disease is dominated by TGFß signalling
In:
Frontiers in genetics
DOI: https://doi.org/10.3389/fgene.2020.00372
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Survival of Activated Myofibroblasts in Canine Myxomatous Mitral Valve Disease and the Role of Apoptosis
(8 pages)
In:
Research in Veterinary Science, vol. 128, pp. 99-106
DOI: https://doi.org/10.1016/j.rvsc.2019.11.004
Research output: Contribution to Journal › Article (E-pub ahead of print)