|1973||BSc (Hons) Zoology University College London|
|1976||PhD; Department of Genetics, University of Leicester|
|1977 - 1978||Visiting Fellow, National Institute of Environmental Health Sciences, (NIH), North Carolina, U.S.A.|
|1979 - 1982||Research Fellow , Imperial Cancer Research Fund, London|
|1982 - 1984||SERC Advanced Fellow, School of Biological Sciences, University of Sussex|
|1984 - 1992||Lecturer, Department of Genetics, University of Edinburgh|
|1992 - 1998||Reader, Institute of Cell, Animal and Population Biology|
|1992 - 2000||Convenor, Centre for HIV Research, University of Edinburgh|
|1998 - present||Professor of Evolutionary Genetics, University of Edinburgh|
|2000 - 2002||Visiting Professor, Department of Pathology, University of California San Diego|
|2006||Elected Fellow of the Royal Society of Edinburgh|
|2003 - 2007||Head of Institute, IEB|
- Evolution in Action 2 (BI0012)
- Evolutionary and Ecological Genetics 3 (IP0002)
- Molecular and Cellular Basis of HIV Infection (U00682)
- Molecular Phylogenetics (U03444)
Postgraduate Programme Director: MSc in Quantitative Genetics and Genome Analysis
My area of research is the analysis of genetic variation and evolution of HIV, particularly the evolution of drug resistance. I returned from an appointment as a Visiting Professor at the University of California San Diego in 2002 and retain close links with collegues there.
In current research in Edinburgh we are studying using statistical and machine learning approaches to study the genetic basis of combination antiretroviral drug resistance in HIV and influenza. This work is currently supported by the BBSRC.
I am also analyzing factors influencing transmission of drug resistant strains of HIV, and modelling their future spread. Using HIV sequences obtained in the course of clinical treatment we are able to reconstruct the recent HIV epidemic in the UK to understand the temporal patterns of sexual transmission. This involves collaborations with colleagues in London and elsewhere as part of a UK-wide multicentre study of the drug resistance as a determinant of clinical response to antiretroviral therapy. This work is supported by the Medical Research Council.
For several years we have also been interested in the population genetics of HIV within infected patients and the factors influencing the pattern of mutations conferring drug resistance. This has recently extended to studies of CTL-mediated selection using codon-based models, especially in the coding regions of HIV-1 protease and reverse transcriptase. This work is supported by the NIH.
Pervasive and non-random recombination in near full-length HIV genomes from Uganda
Inferring HIV-1 transmission networks and sources of epidemic spread in Africa with deep-sequence phylogenetic analysis
Phylogeography of HIV-1 suggests that Ugandan fishing communities are a sink for, not a source of, virus from general populations
HIV-1 DNA is Maintained in Antigen-Specific CD4+ T Cell Subsets in Patients on Long-Term Antiretroviral Therapy Regardless of Recurrent Antigen Exposure
Non-disclosed men who have sex with men in UK HIV transmission networks
Recent and rapid transmission of HIV among people who inject drugs in Scotland revealed through phylogenetic analysis
A high HIV-1 strain variability in London, UK, revealed by full-genome analysis
HIV-TRACE (Transmission Cluster Engine)
Recent trends and patterns in HIV-1 transmitted drug resistance in the United Kingdom
Quantifying predictors for the spatial diffusion of avian influenza virus in China