Professor Alan Archibald
Personal Chair of Mammalian Molecular Genetics
Alan L. Archibald is Head of the Division of Genetics and Genomics at The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh. Professor Alan Archibald is internationally recognised in the field of farm animal genetics and genomics research. He co-led the first international farm animal genome project – PiGMaP. Together with Professor Chris Haley he was awarded the Royal Agricultural Society of England’s Research Medal in 1997 for research work of benefit to agriculture. He is a member of the Steering Committee of the Swine Genome Sequencing Consortium that is promoting efforts to sequence the pig genome and chair of the Governing Council of the European Animal Disease Genomics network of Excellence for Animal Health and Food Safety.
His research is concerned with understanding the genetic control of complex traits, including production efficiency, product quality and host response to infectious disease, mainly in pigs and cattle. His current research of relevance to this conference includes dissecting the genetic control of predisposition to boar taint.
He has a personal chair in Mammalian Molecular Genetics in the Royal (Dick) School of Veterinary Studies at the University of Edinburgh and is as a Fellow of the Royal Society of Edinburgh which is Scotland’s National Academy of Science and Letters.
1981 Doctor of Philosophy (PhD), University of Edinburgh Bovine serum amylase polymorphism
1973 Bachelor of Science, University of Edinburgh
Responsibilities & affiliations
External Committees Swine Genome Sequencing Consortium – steering committee (Alan Archibald)
ELIXIR Scientific Advisory Board (Alan Archibald)
Scientific Impact and Advisory Board - Institute of Biological, Evironmental and Rural Sciences (IBERS), University of Aberystwyth (Alan Archibald)
Scientific Advisory Committee – Animal Health Trust, Newmarket (Alan Archibald)
Knowledge Transfer Network, Animal Sector Advisory Board (Alan Archibald)
BBSRC Animal Health Research Club Steering Group(Alan Archibald)
The Roslin Institute Science Management Group (Alan Archibald) The Roslin Institute Finance and Contracts Committee (Alan Archibald) Edinburgh Genomics Governance Board (Alan Archibald)
Postgraduate students, Honours students
Previous students: Sorensen G, Host-virus interactions in Porcine Reproductive and Respiratory Syndrome virus infection. (PhD, 2014)
Hernandez SC, Genetics of litter size and prenatal survival in pigs. (PhD, 2011)
King AH, Identification of candidate genes controlling porcine female reproductive traits (PhD, 2003)
Kathirvel P, Mapping and manipulation of the murine ryanodine receptor gene (Ryr1) (PhD, )
George S, Physical mapping of the murine casein locus (PhD, 1996)
Understanding the genetic control of complex traits, including responses to infectious disease, in farmed animals, primarily pigs and cattle.
Current research interestsWebsites This research group is an active participant in several international collaborative projects and networks including: Functional Annotation of Animal Genomes (FAANG) www.faang.org COST Action CA15112 Functional Annotation of Animal Genomes - European network (FAANG-Europe) www.faang-europe.org Swine Genome Sequencing Consortium see: www.sanger.ac.uk/Projects/S_scrofa FPC physical map available at: http://pre.ensembl.org/Sus_scrofa_map/Info/Index/ Annotated Sscrofa10.2 reference genome sequence available at: http://www.ensembl.org/Sus_scrofa/Info/Index View of Sscrofa10.2 reference genome sequence and aligned clone end sequences available at:http://geval.sanger.ac.uk/PGP_pig_10_2/Info/Index International Sheep Genomics Consortium see:http://www.sheephapmap.org/ Annotated Oar_v3.1 reference genome available at:http://www.ensembl.org/Ovis_aries/Info/Index
Functional annotation of the transcriptome of the pig, Sus scrofa, based upon network analysis of an RNAseq transcriptional atlas
A Gene Expression Atlas of the Domestic Water Buffalo (Bubalus bubalis)
Balancing selection at a premature stop mutation in the myostatin gene underlies a recessive leg weakness syndrome in pigs
Comprehensive transcriptional profiling of the gastrointestinal tract of ruminants from birth to adulthood reveals strong developmental stage specific gene expression
FAANG, establishing metadata standards, validation and best practices for the farmed and companion animal community
Livestock 2.0 – genome editing for fitter, healthier, and more productive farmed animals
Functional Annotation of Animal Genomes (FAANG)
Pigs lacking the scavenger receptor cysteine-rich domain 5 of CD163 are resistant to PRRSV-1 infection
A novel inactivated vaccine against Lawsonia intracellularis induces rapid induction of humoral immunity, reduction of bacterial shedding and provides robust gut barrier function
Analysis of the genetic diversity and mRNA expression level in porcine reproductive and respiratory syndrome virus vaccinated pigs that developed short or long viremias after challenge