Edinburgh Pathology

Guia Cerretelli

PhD student

s1794019@sms.ed.ac.uk

+44 (0)131 5651 8694

 

Cancer Research UK Edinburgh Centre

University of Edinburgh

Western General Hospital

Crewe Road South

Edinburgh EH4 2XR

Intestinal tumour modelling and DNA damage: investigating the role of DNA mismatch repair in ethanol induced colorectal carcinogenesis

Ethanol is a known risk factor for colorectal cancer and is classified (along with its metabolite acetaldehyde) as a group one carcinogen by the International Agency for Research on Cancer. We aim to elucidate the mechanisms of ethanol induced colorectal carcinogenesis, in particular in defective mismatch repair driven tumour formation. Colorectal cancers (CRC) have defective DNA Mismatch Repair (MMR) in ~13% sporadic CRCs mostly due to acquired MLH1 promoter methylation and in ~3% CRCs due to inherited MMR gene mutations in Lynch Syndrome. This project will test the hypothesis that the MMR pathway is involved in repair of some of the ethanol/acetaldehyde-induced DNA base adducts and thus ethanol is likely to accelerate dMMR-driven intestinal tumour formation via unrepaired DNA damage.

Funding body

Pathological Society

Supervisors 

Prof Mark Arends

Dr Susan Farrington