Edinburgh Pathology

Giulia Tagliavini

PhD Student

G.Tagliavini@sms.ed.ac.uk

+44 (0)131 242 9174

 

University of Edinburgh

Room E2-36

The Queen's Medical Research Institute

Edinburgh BioQuarter

47 Little France Crescent

Edinburgh EH16 4TJ

In situ immunophenotyping and identification of macrophage subpopulations critical for bladder cancer growth & metastasis.

Bladder cancer (BC) is the 9th most common malignant disease worldwide and is characterised by frequent recurrence. We know that a permissive immune micro-environment is critical for tumour progression, but, little is known of the immune environment in human bladder cancer and how it may affect progression, recurrence and response to treatment. We hypothesise that macrophages of a specific phenotype create a protective niche for the development of early cancer while a different phenotypic population facilitates invasion and metastasis.

The project will comprehensively map the immune environment with particular emphasis on phenotype and topography of individual tumour associated macrophages (TAM) in clinical biopsies of bladder cancer and investigate how macrophage phenotypes at different locations within the tumour microenvironment characterise the presentation of BC, change with treatment and may predict the clinical outcome and response to treatment.

Funding body

The Melville Trust for the Care and Cure of Cancer

Supervisors 

Dr Sandrine Prost

Dr Binzhi Qian

Collaborators

Dr Marie O'Donnell, Consultant Pathologist, Uropathology specialist

Mr Param Mariappan, Consultant Urological Surgeon and Honorary Clinical Senior Lecturer

Dr Duncan McLaren, Consultant Clinical Oncologist