Edinburgh Pathology

Dr Kate Cuschieri

Director of Human Papillomavirus Research Group

+44 (0)131 242 6039
 

Scottish Human Papilloma Virus Reference Laboratory (SHPVRL)

Specialist Virology Centre

Royal Infirmary of Edinburgh

Edinburgh BioQuarter

51 Little France Crescent

Edinburgh EH16 4SA

Current Research

The HPV Research Group together with the Scottish HPV Reference Laboratory (Department of Laboratory Medicine, RIE) and the Scottish HPV Investigator's Network (SHINe) undertakes research that will help to improve health service provision for the prevention, detection and management of cervical cancer and other HPV related diseases.  A key focus of research is to develop biomarkers for the improved risk-stratification of HPV infection

 Another key remit of the research group is the setup and management of the Scottish HPV Archive. The archive serves as a biobank residual samples including but not confined to cervical liquid based cytology (LBC) samples and DNA from the cervical screening programme.  The samples are well annotated with clinical data and have approval for use in research. With regular quality assessments, we aim to provide researchers with a vital resource to improve the way we detect and manage HPV associated disease

 If you would like to know more about the research we do or are interested in accessing the Archive for your research, please contact us at: hpvarchive@ed.ac.uk

Group Members

Members Name Role Telephone Email    
Dr Ramya Bhatia   Program Manager +44 (0)131 242 6005 Email Ramya Bhatia
Elia Alcaniz Research Technician +44 (0)131 242 6625 Email Elia Alcaniz
Sharon Moncur Research Technician +44 (0)131 242 6625 Email Sharon Moncur
June Stroud Research Technician +44 (0)131 242 6625 Email June Stroud
Jessica Viti MSc student +44 (0)131 242 6625 Email Jessica Viti

Collaborators

  • Prof Juergen Haas (University of Edinburgh
  • Prof Alistair Williams (University of Edinburgh)
  • Prof Maggie Cruickshank (University of Aberdeen)
  • Prof Sheila Graham (University of Glasgow)
  • Prof Marc Arbyn (Belgian Cancer Centre / Unit of Cancer Epidemiology)
  • Prof Attila Lorincz (Queen Mary University of London)
  • Dr Jesper Bonde (Copenhagen University Hospital, Hvidovre)

  • Prof J O Leary & the Cerviva Group (The Coombe Women and Infants University Hospital& Trinity College, Dublin)

Web Links

Selected Publications

Bhatia R, Kavanagh K, Stewart J, Moncur S, Serrano I, Cong D, Cubie HA, Haas JG, Busby-Earle C, Williams ARW, Howie SEM, Cuschieri K. Host chemokine signature as a biomarker for the detection of pre-cancerous cervical lesions. Oncotarget. 2018 Apr 6;9(26):18548-18558. doi: 10.18632/oncotarget.24946. eCollection 2018 Apr 6. PubMed PMID: 29719625; PubMed Central PMCID: PMC5915092.

Bhatia R, Serrano I, Wennington H, Graham C, Cubie H, Boland E, Fu G, Cuschieri K. Evaluation of a Novel Single-Tube Method for Extended Genotyping of Human Papillomavirus. J Clin Microbiol. 2018 Feb 22;56(3). pii: e01687-17. doi: 10.1128/JCM.01687-17. Print 2018 Mar. PubMed PMID: 29237790; PubMed Central PMCID: PMC5824038.

Cuschieri K, Ronco G, Lorincz A, Smith L, Ogilvie G, Mirabello L, Carozzi F, Cubie H, Wentzensen N, Snijders P, Arbyn M, Monsonego J, Franceschi S. Eurogin roadmap 2017: Triage strategies for the management of HPV-positive women in cervical screening programs. Int J Cancer. 2018 Jan 17. doi: 10.1002/ijc.31261. [Epub ahead of print] Review. PubMed PMID: 29341110.

Kavanagh K, Pollock KG, Cuschieri K, Palmer T, Cameron RL, Watt C, Bhatia R, Moore C, Cubie H, Cruickshank M, Robertson C. Changes in the prevalence of human papillomavirus following a national bivalent human papillomavirus vaccination programme in Scotland: a 7-year cross-sectional study. Lancet Infect Dis. 2017 Dec;17(12):1293-1302. doi: 10.1016/S1473-3099(17)30468-1. Epub 2017 Sep 28. PubMed PMID: 28965955.

Cuschieri K, Geraets D, Cuzick J, Cadman L, Moore C, Vanden Broeck D, Padalko E, Quint W, Arbyn M. Performance of a Cartridge-Based Assay for Detection of Clinically Significant Human Papillomavirus (HPV) Infection: Lessons from VALGENT (Validation of HPV Genotyping Tests). J Clin Microbiol. 2016 Sep;54(9):2337-42. doi: 10.1128/JCM.00897-16. Epub 2016 Jul 6. PubMed PMID: 27385707; PubMed Central PMCID: PMC5005513.