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Study gives insight into motor neurons

Scientists have discovered a new way to generate human motor nerve cells in a development that will help research into motor neurone disease.

Researcher have created a range of motor neurons from human embryonic stem cells in the laboratory.

Motor neurons are nerve cells that send messages from the brain and spine to other parts of the body.

Motor neurons

It is the first time that researchers have been able to generate a variety of human motor neurons.

Motor neurons differ in their make-up and display different properties depending on where they are located in the spinal cord.

The research involved a team from the Universities of Edinburgh, Cambridge and Cardiff and is published in the journal Nature Communications.

Motor neurons differ in their make-up, so understanding why some are more vulnerable than others to disease is important for developing treatment for this devastating condition.

Professor Siddharthan ChandranDirector of the Euan MacDonald Centre for Motor Neurone Disease Research

Implications

The work could help scientists better understand motor neurone disease.

The process will enable scientists to create different types of motor neurons.

This will help them study why some are more vulnerable to disease than others.

Motor neurone disease

Motor neurons control muscle activity such as speaking, walking, swallowing and breathing.

However, in motor neurone disease - a progressive and ultimately fatal disorder - these cells break down.

This leads to paralysis, difficulty speaking, breathing and swallowing.

Generating motor neurons

Previously scientists had only been able to generate one particular kind of motor neuron, which they did by using retinoic acid, a vitamin A derivative.

In the latest study, scientists have found a way to generate a wider range of motor neurons using a new process without retinoic acid.

Although motor neurons are often considered as a single group, they represent a diverse collection of neuronal subtypes. The ability to create a range of different motor neurons is a key step in understanding the basis of selective subtype vulnerability in conditions such as motor neuron disease and spinal muscular atrophy.

Dr Rickie PataniUniversity of Cambridge