MS maps reveal regional variation in Scotland

Orkney continues to top the table for rates of multiple sclerosis in Scotland, a study has revealed.

Tayside has the highest incidence of the disease in mainland Scotland, while the central belt and Borders have the lowest rates of MS.

The findings provide the first detailed snapshot of people affected by the disease across the country.

Scottish Multiple Sclerosis Register

They are from the Scottish Multiple Sclerosis Register – a national database with records of people diagnosed since 2010.

The study confirms that Scotland has one of the highest rates of MS diagnosis in the world. It reveals that incidence of the disease varies substantially between regions, even on the mainland.

Rates of diagnosis were three times higher in Orkney than the central belt and Borders, researchers found.

Gender difference

Women are particularly susceptible, with rates of the disease double that of men.

For example, a woman in Orkney has a one in 50 chance of developing MS during her lifetime compared with around one in 600 for a man living in the Borders.

Latitude effect

The study adds weight to previous findings that disease rates are greater in northern regions but suggests that other factors may also be important.

Figures showed incidence of the disease in Shetland is more than one-third lower than in Orkney, despite Shetland being located farther north. Rates of MS in Tayside are almost double those in Lothian, however.

Colour-coded map of MS incidence across Scotland
Colour-coded map shows variation in incidence of multiple sclerosis across Scotland.

Powerful resource

Lead researcher Dr Patrick Kearns said the Scottish MS Register is a powerful resource and the result of substantial far-sighted investment.

He said it builds on the strength of the NHS in Scotland and allows researchers to study geographical risk factors in detail.

Future research

Further studies are needed to probe the underlying causes of regional and gender differences, the team says.

The research was led by the Anne Rowling Regenerative Neurology Clinic at the University of Edinburgh. It is published in the Journal of Neurology.

There is much more work to be done, not least to further ensure the accuracy and precision of the register. However, our hope is that by understanding more precisely where the areas of higher and lower risk are found in Scotland, we can start to work out why.

Dr Patrick KearnsRowling Scholars Training Fellow, Anne Rowling Regenerative Neurology Clinic 

Related links

Journal article

Anne Rowling Regenerative Neurology Clinic

Centre for Clinical Brain Sciences

Study at Edinburgh Medical School