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Chicken cells gene-edited to resist bird flu

Scientists have used gene-editing techniques to stop the bird flu virus from spreading in chicken cells grown in the lab.

The findings raise the possibility of producing gene-edited chickens that are resistant to the disease.

DNA deletion

Researchers prevented the virus from taking hold by deleting a section of chicken DNA inside lab-grown cells.

The next step will be to try to produce chickens with the genetic change. No birds have been produced yet, the team says.

Virus infection

Scientists targeted a specific molecule inside chicken cells called ANP32A. Researchers at Imperial College London found that during an infection, flu viruses hijack this molecule to help replicate themselves.

Working with experts from the University of Edinburgh’s Roslin Institute, the researchers used gene-editing techniques to remove the section of DNA responsible for producing ANP32A.

They found the virus was no longer able to grow inside cells with the genetic change.

We haven’t produced any birds yet and we need to check if the DNA change has any other effects on the bird cells before we can take this next step.

Dr Mike McGrewThe Roslin Institute

Avian flu

Bird flu is a major threat to farmed chickens worldwide, with severe strains killing up to 100 per cent of birds in a flock.

In rare instances, certain variations of the virus can infect people and cause serious illness. Efforts to control the spread of the disease are urgently needed.

Previous research

Researchers at The Roslin Institute previously worked with experts from Cambridge University to produce chickens that did not transmit bird flu to other chickens following infection, using genetic modification techniques.

The new approach is different because it does not involve introducing new genetic material into the bird’s DNA.

Pandemic prevention

Professor Wendy Barclay, Chair in Influenza Virology at Imperial College London, said the approach has the potential to stop the next flu pandemic at its source.

Avian influenza resistance in broiler production is of global significance and this research is an important step toward that goal.

Rachel HawkenSenior Director of Genomics and Quantitative Genetics, Cobb-Vantress

The study was funded by the Biotechnology and Biological Sciences Research Council, which also provides strategic funding to The Roslin Institute. PhD student funding was provided by the global poultry research company Cobb-Vantress. The research is published in the journal eLife.

Related links

Journal article

The Roslin Institute

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