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Two simple tests could help to pinpoint cause of stroke

Detecting the cause of the deadliest form of stroke could be improved by a simple blood test added alongside a routine brain scan, research suggests.

Combining the test with a brain scan could provide key genetic information that may help identify those most at risk from a second stroke, doctors say.

Experts say the new approach could revolutionise the way doctors manage strokes caused by bleeding in the brain, known as intracerebral haemorrhage (ICH).

ICH accounts for up to 50 per cent of all strokes worldwide. Around half of those affected die within one year.

Researchers used the blood test and brain scan images to detect a condition known as cerebral amyloid angiopathy (CAA), which can cause ICH and is linked to a higher risk of further strokes and dementia.

CAA is caused by a build-up of a protein known as amyloid in the walls of blood vessels in the brain.

University of Edinburgh researchers used computed tomography (CT) scans in more than 100 patients who died following their first ICH. They collected blood samples to test a gene called APOE, which is linked to CAA.

Identifying the cause of a brain haemorrhage is important to planning patient care. Our findings suggest that the combination of routine CT scanning with APOE gene testing can identify those whose ICH has been caused by CAA – a group who may be more at risk of another ICH or dementia.

Dr Mark RodriguesWellcome Trust Clinical PhD Programme Fellow, University of Edinburgh

By combining simple CT scan images with a genetic blood test, researchers could accurately spot if an ICH had been caused by CAA.

This new approach could help identify people who are at higher risk after their ICH, scientists say.

It could also improve ICH diagnosis in developing countries as CT scanning and blood testing is available worldwide.

The study is published in Lancet Neurology and was funded by the Medical Research Council, Stroke Association and Wellcome Trust.

An intracerebral haemorrhage or bleed in the brain can be devastating.  This important study suggests a new way to identify what contributed to someone having an intracerebral haemorrhage. It may help doctors better understand which patients are at most risk of further stroke and plan patient care.​​​​

Dr Shamim QuadirResearch Communications Manager, the Stroke Association

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Original article

Centre for Clinical Brain Sciences