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Therapy hope for deadly breathing condition

Fresh insights into a life-threatening lung condition triggered by blood poisoning could signal a new approach to treating the disease.

Scientists have found that a drug, which targets key immune cells, could help to curb excessive inflammation in the lungs that is linked to the condition.

The researchers say more studies are needed, but their findings from tests on patients’ cells are promising.

Immune cell influx

Acute Respiratory Distress Syndrome (ARDS) is a life-threatening condition caused by an overwhelming influx of a type of immune cell into the lungs during an infection.

These cells – called neutrophils – are initially brought in to fight the infection but they can also inflict significant damage on the lung.

Self-destruct

At the end of an infection, neutrophils usually self-destruct in a controlled manner to prevent bystander damage to healthy tissues.

In ARDS, the cells survive for longer and this is thought to contribute to a worsening of the condition.

New approach

Researchers at the University of Edinburgh sought to investigate whether targeting neutrophils could offer a useful approach to treating the condition.

They found that treating neutrophils taken from patient blood samples with a drug called AT7519 helped to restore the cells’ normal self-destruct process.

After 20 hours of treatment in the laboratory, the cells behaved like those of healthy people.

Therapy hope

The findings suggest that AT7519 could offer a useful therapy to resolve inflammation in the lung in patients with ARDS.

Our findings suggest that this drug warrants further investigation as a potential therapy for Acute Respiratory Distress Syndrome, which is a devastating condition that kills up to half of those affected.

Professor Adriano RossiMRC Centre for Inflammation Research, University of Edinburgh

Respiratory distress

ARDS results in severe breathing difficulties that requires treatment in intensive care. Up to half of people who develop the condition do not survive as there are currently no effective treatments. Patients are usually placed on a ventilator to help them breathe until the inflammation resolves.

Cancer drug

AT7519 belongs to a family of drugs called cyclin-dependent kinase inhibitors and is currently being trialled as a cancer therapy.

More studies are needed but researchers are optimistic that AT7519 could eventually be tested as a treatment for ARDS in patients.

The study, by the Medical Research Council Centre for Inflammation Research, is published in the journal Thorax.

Related links

Journal article

MRC Centre for Inflammation Research

Edinburgh Medical School