Quantitative Traits in Health and Disease
My core research interest is in the study of the genetics of quantitative traits (QTs) and their relationship to health and disease. I study the genetics of populations from Croatia and Scotland, in which a wide range of data was collected from medical examinations, questionnaires and biochemical assays. Plasma, serum and urine have been stored from each cohort participant, allowing additional lab-based measures to be derived, and new hypotheses to be tested. Recent advances in Electronic Health Record linkage has increased the availability of clinical measures and enables the longitudinal follow-up of participants which can then be associated with genetic factors.
I have a major interest in kidney-related traits and lead a European Consortium of Urinary Traits as well as being a participating member of the Chronic Kidney Disease Genetic consortium (CKDGen).
The diversity of phenotypes measured in these cohorts has enabled my research to cover quantitative traits relevant to a very broad spectrum of medically relevant conditions including lung function, pain, heart disease and the consequences of germline viral integration.
|Caroline Hayward||Group Leader|
|Shona Kerr||Project Manager|
|Susan Campbell||Technical Support|
|Lucija Klaric||PhD Student|
|Anne Richmond||Data Analyst|
|Christina Joseph||PhD student|
human genetics, quantitative traits, isolate populations, kidney function, disease mechanisms, phenotyping, linkage, 'omics,
GWAS, Quantitative genetics, Genomics, genotype analysis, electronic health record linkage