MRC Human Genetics Unit
Medical Research Council Human Genetics Unit

Jose Luis Garcia-Perez Research Group

Regulation of LINE-1 Retrotransposition

Jose L Garcia Perez
Dr Jose Luis Garcia Perez - IGMM Chancellor's Fellow

Section: Disease Mechanisms

Research in a Nutshell 

Despite its size, it is remarkable that all the human genes together do not comprise more than 5% of our genome. This is because a large fraction of our genome is made of regulatory sequences to ensure proper functioning of our genome. However, it is surprising that almost half of our genome is made of repetitive sequences. Intriguingly, some repetitive DNA sequences from our genome have the ability to move within our genome and are termed Mobile DNA. Mobile DNA induced changes can affect the organization and the regulation of our genome. Our lab tries to understand how mobile DNA in our genome impacts both natural variability among humans and human disease. To do that, we combine genetics, biochemistry and animal models to understand how mobile DNA can result in a new genetic disorder and to describe how our genome reacts to the activity of Mobile DNA.

People

 
Jose Luis Garcia-Perez Group Leader
Emilie Debladis Research Fellow

 Contact

Jose.Garcia-Perez@igmm.ed.ac.uk

Collaborations

  • Dr Ian Adams, University of Edinburgh. 
  • Dr Geoff Faulkner, University of Queensland, Australia.
  • Dr John Moran, University of Michigan Medical School, US.
  • Dr John Goodier, John Hopkins Medical School, US

Partners and Funders

  •  The Wellcome Trust-University of Edinburgh Institutional Strategic Support Fund

Scientific Themes

Retrotransposons, Genome Stability, Stem Cells, DNA-repair

Technology Expertise

Next Generation DNA sequencing, Embryonic Stem Cells, induced pluripotent stem cells, zebrafish models