Regulation of LINE-1 Retrotransposition
Despite its size, it is remarkable that all the human genes together do not comprise more than 5% of our genome. This is because a large fraction of our genome is made of regulatory sequences to ensure proper functioning of our genome. However, it is surprising that almost half of our genome is made of repetitive sequences. Intriguingly, some repetitive DNA sequences from our genome have the ability to move within our genome and are termed Mobile DNA. Mobile DNA induced changes can affect the organization and the regulation of our genome. Our lab tries to understand how mobile DNA in our genome impacts both natural variability among humans and human disease. To do that, we combine genetics, biochemistry and animal models to understand how mobile DNA can result in a new genetic disorder and to describe how our genome reacts to the activity of Mobile DNA.
|Jose Luis Garcia-Perez||Group Leader|
|Emilie Debladis||Research Fellow|
Retrotransposons, Genome Stability, Stem Cells, DNA-repair
Next Generation DNA sequencing, Embryonic Stem Cells, induced pluripotent stem cells, zebrafish models