MRC Human Genetics Unit
Medical Research Council Human Genetics Unit

SDRN Type 1 Bioresource (SDRNT1BIO)

The Scottish Diabetes Research Network Type 1 Bioresource facilitates a wide range of research to better understand the determinants of type 1 diabetes and its complications, and the early detection of complications.

The SDRN Type 1 Bioresource (SDRNT1BIO) was established during 2010-13 to support collaborative research.  6,127 participants, aged 16 years and older, from across 10 Scottish NHS Health Boards, volunteered to be part of this research when they were asked during their review visits at hospital and GP clinics. 

Purpose 

The purpose of the SDRNT1BIO is to facilitate a wide range of research into diabetes and its complications.

Aims 

The main aims of the SDRNT1BIO are:

  1. Discovery and validation of genetic determinants of type 1 diabetes
  2. Discovery and validation of genetic determinants of complications of type 1 diabetes
  3. Identifying the genetic biomarkers of diabetes complications 
  4. Identifying subgroups (stratification) of apparent type 1 diabetes 
  5. Environmental and socio-economic determinants of type 1 diabetes

Information in SDRNT1BIO

Participants provided blood samples which are now stored as a bioresource of serum, plasma, urine and DNA. 

Physical measurements including blood pressure and waist-hip ratio were taken.

Participants completed a questionnaire covering their diabetes diagnosis and treatment, history of any diabetes complications, and lifestyle factors such as physical activity, smoking and alcohol habits. 

Also, the SDRNT1BIO has been comprehensively genotyped. This means that the genetic characteristics of an individual, their ‘genotype’, has been determined by examining their DNA sequence.  

93% of participants gave their consent to be involved in future studies, in-person (face-to-face), and 100% gave consent through their electronic health care records. 

94% of participants consented for their spare blood samples taken at their routine tests at diabetic clinics to be added to the bioresource. 

Links to other databases

H.Colhoun research

All of the SDRNT1BIO participants also consented for their anonymised data from the Scottish national clinical diabetes database (SCI-DC) and national health data to be linked to the SDRNT1BIO. 

These data linkages include data on hospital admissions, annual diabetic clinical reviews, retinopathy screening, renal replacement register, and prescriptions.

Together these data linkages provides a world-leading data resource for researchers investigating type 1 diabetes and its related complications. 

Researchers analyse this data to identify patterns and trends, and produce prediction models to help clinicians advise people on the care of their diabetes and diabetes complications.