MRC Human Genetics Unit
Medical Research Council Human Genetics Unit
MRC Human Genetics Unit
Institute of Genetics and Cancer
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Current research SDRNT1BIO

Research using the SDRNT1BIO is aiming to identify those most at risk of complications, and to investigate potential early-warning signs of possible future complications.

Current Projects 

The current research projects in 2017-18 are:

  • Genome wide single nucleotide polymorphism (SNP) data in a large cohort of people with Type 1 Diabetes (funded by Diabetes UK) 
  • Characterising the Extremes of Liability to Diabetic Complications (funded by JDRF). 
  • Validation of Novel and Candidate Biomarkers for Diabetic Kidney Disease in Large Cohorts of people with type 1 diabetes (funded by JDRF). 
  • Predictors of Early Stage Decline in Kidney Function in Type 1 Diabetes Diabetic Nephropathy Biomarker Discovery and Validation Using Type 1 Diabetes Cohorts (funded by JDRF). 
  • Epidemiology of Persistent C-Peptide and Its Association with Complications and Other Features in the SDRN Type 1 Bioresource: Potential Mechanisms of Persistence of C-peptide in Established Type 1 Diabetes.   
SDRNT1BIO Collaborations
SDRNT1BIO Collaborations

Collaboration 

The project work involves a wide number of collaborations, including with: 

  • Universities: Cambridge, California, Dundee, Exeter, Glasgow, Harvard, King’s College London, Michigan, Pittsburgh, Toronto, Washington, Wisconsin 
  • Research Centres: Broad Institute, Folkhälsan, Generation Scotland, Genos, Joslin diabetes Center, Steno Diabetes Center 

Interested collaborators should contact the Study Co-ordinator in the first instance, email SDRN.T1BIO@ed.ac.uk

Published Papers 

Cohort Profile: Scottish Diabetes Research Network Type 1 Bioresource Study (SDRNT1BIO). Published by the International Journal of Epidemiology, October 2016

 

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