MRC Human Genetics Unit
Medical Research Council Human Genetics Unit

Current research SDRNT1BIO

Research using the SDRNT1BIO is aiming to identify those most at risk of complications, and to investigate potential early-warning signs of possible future complications.

Current Projects 

The current research projects in 2017-18 are:

  • Genome wide single nucleotide polymorphism (SNP) data in a large cohort of people with Type 1 Diabetes (funded by Diabetes UK) 
  • Characterising the Extremes of Liability to Diabetic Complications (funded by JDRF). 
  • Validation of Novel and Candidate Biomarkers for Diabetic Kidney Disease in Large Cohorts of people with type 1 diabetes (funded by JDRF). 
  • Predictors of Early Stage Decline in Kidney Function in Type 1 Diabetes Diabetic Nephropathy Biomarker Discovery and Validation Using Type 1 Diabetes Cohorts (funded by JDRF). 
  • Epidemiology of Persistent C-Peptide and Its Association with Complications and Other Features in the SDRN Type 1 Bioresource: Potential Mechanisms of Persistence of C-peptide in Established Type 1 Diabetes.   
SDRNT1BIO Collaborations
SDRNT1BIO Collaborations

Collaboration 

The project work involves a wide number of collaborations, including with: 

  • Universities: Cambridge, California, Dundee, Exeter, Glasgow, Harvard, King’s College London, Michigan, Pittsburgh, Toronto, Washington, Wisconsin 
  • Research Centres: Broad Institute, Folkhälsan, Generation Scotland, Genos, Joslin diabetes Center, Steno Diabetes Center 

Interested collaborators should contact the Study Co-ordinator in the first instance, email SDRN.T1BIO@ed.ac.uk

Published Papers 

Cohort Profile: Scottish Diabetes Research Network Type 1 Bioresource Study (SDRNT1BIO). Published by the International Journal of Epidemiology, October 2016