MRC Human Genetics Unit
Medical Research Council Human Genetics Unit


We are currently looking to recruit postdoctoral scientists to join our research team.



Self-DNA activating innate immunity in autoinflammation and genome instability


A postdoctoral researcher is sought for a three-year post in the lab of Prof. Andrew Jackson FRS, to characterise cellular sources of DNA that drive inflammation.

DNA is a potent molecular pattern inducing innate immune responses to pathogens, but also our own DNA. Pathways that recognise such nucleic acids or prevent their accumulation have been widely implicated in monogenic interferonopathies, genome stability disorders and neoplasia.

The successful candidate will extend the lab’s previous work that demonstrated detection of micronuclei by the cGAS-STING pathway (Mackenzie et al, Nature, 548:461). Through the study of interferonopathies and genome instability disorders, we will identify additional cell-intrinsic sources of DNA and define how these activate innate immunity, to gain novel insights into the genesis of autoimmune disease and cancer.

The post would particularly suit an early-stage postdoctoral researcher who is interested in working in a cross-disciplinary environment that addresses both fundamental cellular processes and disease mechanisms. Candidates will need to demonstrate a strong track record and previous experience in cell biology or molecular immunology. Applicants with prior experience in the field of innate immunity or the cell biology of genome instability are particularly encouraged to apply.

The research group is international, with 12 papers published in Cell and Nature journals in the last 10 years.


Informal enquiries can be made to:

For more information and details of how to apply.