MRC Human Genetics Unit
Medical Research Council Human Genetics Unit

Yanick Crow elected as Royal Society Fellow

Professor Crow has been elected as a Royal Society Fellow in recognition of his work on human genetic disease: May 2024

Yanick Crow portrait

Yanick Crow, a clinician scientist at the MRC Human Genetics Unit, Institute of Genetics and Cancer, Edinburgh and the Institut Imagine, Paris, was one of 90 Fellows, Honorary Fellows and Foreign Members elected today to the Royal Society. He leads research driven by an interest in human Mendelian diseases and a determination to improve their diagnosis and treatment.

The work of Professor Crow’s group on the genetic inflammatory disorder Aicardi-Goutières syndrome (AGS) has helped to link specific mutations in the AGS-related genes to discrete clinical phenotypes, identify mechanisms explaining how nucleic acids in the cell can lead to autoinflammation and autoimmunity, and further implicate type I interferon signalling in the pathogenesis of other more common disorders, particularly systemic lupus erythematosus.

Beyond AGS, Crow’s work has defined a novel group of inborn errors of metabolism associated with an upregulation of type I interferon signalling – the ‘type I interferonopathies’. Given the clear unmet clinical need for treatments for these conditions, Professor Crow and colleagues are focussed on better understanding fundamental mechanisms relevant to autoinflammation and autoimmunity, and the search for therapies aimed at blocking nucleic acid driven inflammation.

The Royal Society is an independent Fellowship made up of the most eminent scientists, engineers and technologists from across the scientific landscape and from all over the world. Fellows and Foreign Members are elected for life through nomination from existing members and a peer review process on the basis of excellence in science.