Regulation and function of the nonsense-mediated decay (NMD) pathway
Supervisor: Professor Javier F. Caceres
The Nonsense-mediated decay (NMD) pathway selectively degrades mRNAs harboring premature termination codons (PTCs), preventing the synthesis of truncated proteins. We study the mechanism and physiological relevance of NMD. We have identified an NMD pathway at the Endoplasmic Reticulum (ER) that provides quality control of ER-translated mRNAs1. We will focus on the mechanism and physiological role of the ER-NMD pathway, as well as on the biological consequences of manipulating its activity.
Longman et al. (2020) Identification of a localized nonsense-mediated decay pathway at the endoplasmic reticulum. Genes Dev 34: 1075-1088