MRC Human Genetics Unit
Medical Research Council Human Genetics Unit

Revealing the secrets of good and bad white adipose tissue stem cells through single-cell transcriptomic and epigenetic profiling

Professor Bob Hill

Hill research

Obesity is a global epidemic, and analysis of adipose tissue holds the secrets for its prevention. The ‘good’ and ‘bad’ properties associated with subcutaneous and visceral white adipose tissue, respectively, are due to their intrinsic cellular composition. Better understanding of expansion, proliferation and differentiation of adipose cells, and the inflammatory signals that they secrete is central to tackling obesity. This project will investigate the gene expression profiles that determine visceral and subcutaneous adipose progenitor cell fate using the cutting-edge techniques of single cell RNA-seq and ATAC-seq for an in-depth examination of cellular differences and the regulatory landscape responsible for defining cell type.