Beyond Genomics: Using multiOmics data to explore disease causation

Dr Pau Navarro

Using genetic markers (SNPs) and disease information from thousands of individuals, Genome-Wide Association Studies have uncovered genetic loci that cause disease. We also know that epigenetic mechanisms- changes in a chromosome other than changes in DNA sequence- play an important role in determining disease by affecting phenotypes through regulation of gene activity and expression. DNA methylation is a type of epigenetic modification.

We will analyse large scale phenotypic, genomic and epigenomic data and integrate it with publicly available expression databases and local proteomic data to elucidate the mechanism through which variation in genotypes (SNPs) affects methylation and disease.