Genetics
Techniques to study heredity and the variation of inherited characteristics.
Genetics Core of the Edinburgh Clinical Research Facility (ECRF)
Based in: Institute for Genetics and Cancer (IGC) but serving researchers across the College.
Facility manager/ lead contact: Mr Lee Murphy
The Genetics Core team can provide support for clinical research from sample collection to genetic analysis, working to the principles of Good Clinical Practice for Laboratories.
DNA Sanger sequencing service
Based in: IGC
Lead contact: DNA sequencing services
This service provides a Sanger sequencing/genotyping service to all University researchers. The service is operated by two experienced technicians and the main operating platform is a 96 capillary 3730 xl. The standard set-up provides read lengths of up to ~1000bp. Longer read lengths are possible and, if required, the length can be increased.
In addition, the facility can offer a human cell line authentication service.
DNA Sanger sequencing service website
Please note that the booking service from this website is only open to researchers based in IGC, but contact details are provided for others who may wish to use the service.
Bioinformatics Analysis Core
Based in: IGC
Facility Manager/ lead contact: Dr Alison Meynert
The Bioinformatics Analysis Core (BAC) provides advice, training, the provision of computational tools and collaborative expertise to all IGC researchers.
The facility has a track record in the analysis of novel, high throughput biological datasets, particularly sequencing data, and has co-authored many IGC publications and grant proposals.
The BAC has three broad aims, which together constitute its mission statement:
- support: consultation on and provision of collaborative bioinformatics skills to research programmes across the Institute.
- expertise: development and implementation of effective analysis strategies for common tasks, establishing best practice in Institute data analysis.
- training: provision of training resources, instruction and advice to assist Institute users in their own data analysis.
Consultations are available to individual researchers and groups to address questions about your data, possible analyses and associated issues. Please contact the facility by email in the first instance, describing your project (PI name, datasets involved, analyses envisaged, hypotheses to be addressed, intended timelines etc) as accurately as possible.
The BAC also runs the IGC Genomic Data Analysis Centre, which provides standard sequence analysis methods at commercial rates.
Single-cell multi-omics
Based in: Centre for Regenerative Medicine (CRM), BioQuarter campus
Facility manager/ lead contact: Dr Andrea Corsinotti
The facility is equipped with a 10x genomics chromium controller that allows us to generate single cell genomic and transcriptomic data (RNA-seq, ATAC-seq, etc.) from up to 10,000 cells and from multiple samples in parallel, and can offer a fully supported sample preparation service: from cells to libraries that includes QC, quantification and lab consumables.
Single-cell multi-omics facility website
Related links
Genomics at Edinburgh is a network and hub for all genomics research at the University, with a comprehensive website showcasing all genomics research and related facilities across campuses.