Tissue Repair student Pieter Louwe contributes to paper in J Immunol

Tissue Repair student Pieter Louwe co-authors paper about mononuclear phagocytes in J Immunol.

Second year Tissue Repair PhD student Pieter Louwe, who works in the lab of Dr Steve Jenkins, has contributed to a study about mononuclear phagocytes, which was published in The Journal of Immunolgy. The paper was featured on the journal's front cover.

Given the continued interest in macrophages as possible vehicles for delivery of gene therapies and as targets of therapeutics, dissecting how different mononuclear phagocytes regulate CSF1R activity remains an important question. The paper descibes a mouse model which provides a new tool to dissect the differentiation and function of the heterogeneous populations of mouse tissue mononuclear phagocytes and the homeostatic roles of CSF1.

The paper, titled 'Csf1r-mApple Transgene Expression and Ligand Binding In Vivo Reveal Dynamics of CSF1R Expression within the Mononuclear Phagocyte System' can be accessed via the link below.

Hawley CA et al, J Immunol March 15, 2018, 200 (6) 2209-2223