Tissue Repair Postgraduate Training Programme

Campbell et al review role of ageing and parenchymal senescence on macrophage function and fibrosis

Review paper by Tissue Repair student Ross Campbell discusses senescent cells in diseases of kidneys and other organs.

A potential interaction between macrophages and senescent cells within the kidney, however this can only be confirmed using additional specific markers for macrophages and senescent cells
IHC image of mouse kidney, showing F4/80 positive cells in green (mature macrophages), associating with p21CIP1 positive cells in red (senescent cells). Image: RA Campbell.

Ross Campbell, a Wellcome Trust Tissue Repair PhD student in the Ferenbach lab at the Centre for Inflammation Research has published a review article in Frontier in Immunology. For his PhD Ross is investigating how acute and chronic senescence of cells of the kidney influence the macrophages of the immune system and what outcome this has on the diverse roles of macrophages in repair and inflammation.

In the review Ross and colleagues discuss the role of ageing and parenchymal senescence on macrophage function and fibrosis. They explore senescent cells and the overlap between the direct biological impact of senescence and the indirect effects it has via its effects on other cell types, in particular macrophages. Roles of macrophages in cell clearance and in other physiological functions are examined with reference to their functions in diseases of the kidney and other organs. The authors explore the translational potential of different macrophage-based approaches for potential future interventions targeting senescent cells, that may prevent or reverse pathologies with involvement of senescent cells.

Campbell RA et al. Front Immunol 2021;17 June.