Institute of Genetics and Cancer

Vacancies

Current vacancies within the Institute of Genetics and Cancer (formerly the Institute of Genetics and Molecular Medicine - IGMM)

 A summary of current vacancies is provided below. Queries can be directed to the contact provided within the job vacancy or email Human Resources: hr@igc.ed.ac.uk

Research Coordinator

Centre: MRC Human Genetics Unit, Edinburgh, EH4 2XU, GB

Closing Date: 18.05.22

We are looking for a talented and organised administrator with good science communication skills and a broad understanding of biomedical research. You will provide expert flexible support in administration and communication to the MRC Human Genetics Unit.  You will support our researchers by coordinating internal and external meetings and events, capturing research outputs and ensuring compliance with funding and governance requirements. You will use your excellent communication skills help raise the profile of the Unit by supporting dissemination of and engagement with Institute research by a variety of partners and audiences, including via web, social media and supporting public engagement events.

The Opportunity:

Your skills and attributes for success: •    Strong interpersonal, organisation and communication skills  •    Demonstrable ability to write with accuracy in a clear, concise and engaging way for the target audience  •    Ability to input and retrieve data and prepare simple summary reports from research data systems •    Degree in a scientific discipline relevant to biomedical research •    Postgraduate experience in research or research management 

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Research Fellow / Research Software Engineer

Centre: Western General Hospital, Edinburgh, EH4 2XU, GB

Closing Date: 22/05/2022

We are looking for a Postdoctoral Researcher or a Research Software Engineer to join the research group developing the QuPath open-source software (http://qupath.github.io).

This position will focus on improving QuPath’s user experience and data visualization capabilities.

The Opportunity:

This position offers the successful candidate an exciting opportunity to impact research worldwide – by becoming part the small team that develops one of the most popular open-source software applications for bioimage analysis.

Extracting meaningful information from complex biomedical images is hard – but we want to change that. QuPath is open-source, user-friendly, scriptable and extensible software that aims to make sophisticated image processing and artificial intelligence techniques accessible and intuitive. QuPath has been downloaded more than 200,000 times and is used by scientists worldwide in both academia and industry, across a wide range of applications in basic, veterinary and clinical research. Its growing importance to the research community is reflected in over 1,100 citations in scientific publications (Scopus), which includes 568 published in 2021 alone.

A key part of QuPath’s success is that it is developed in connection with specific research projects and in collaboration with its users. QuPath’s large and diverse user-community is supported through GitHub (http://github.com/qupath/qupath), the Scientific Community Image Forum (http://forum.image.sc/tag/qupath), ReadTheDocs (http://qupath.readthedocs.io) and YouTube (https://www.youtube.com/c/qupath).

This position provides a unique opportunity to directly engage with and enhance the work of thousands of researchers. The specific focus is on improving the user experience and data visualization in QuPath, alongside helping the group support and train other users. It will provide opportunities to be creative and to innovate at different levels: from implementing small quality-of-life improvements that make the software easier to use, to tackling the big computational challenges involved in visualizing and interacting with large, multidimensional datasets.

This job is normally based in Edinburgh, but is compatible with remote/hybrid working from within the UK.

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Research Fellow / Research Software Engineer

Centre: Western General Hospital, Edinburgh, EH4 2XU, GB

Closing Date: 22/05/2022

We are looking for a Postdoctoral Researcher or a Research Software Engineer to join the research group developing the QuPath open-source software (http://qupath.github.io).

This position will focus on improving QuPath’s core architecture, performance, scalability and API.

The Opportunity:

This position offers the successful candidate an exciting opportunity to impact research worldwide – by becoming part the small team that develops one of the most popular open-source software applications for bioimage analysis.

Extracting meaningful information from complex biomedical images is hard – but we want to change that. QuPath is open-source, user-friendly, scriptable and extensible software that aims to make sophisticated image processing and artificial intelligence techniques accessible and intuitive. QuPath has been downloaded more than 200,000 times and is used by scientists worldwide in both academia and industry, across a wide range of applications in basic, veterinary and clinical research. Its growing importance to the research community is reflected in over 1,100 citations in scientific publications (Scopus), which includes 568 published in 2021 alone.

A key part of QuPath’s success is that it is developed in connection with specific research projects and in collaboration with its users. QuPath’s large and diverse user-community is supported through GitHub (http://github.com/qupath/qupath), the Scientific Community Image Forum (http://forum.image.sc/tag/qupath), ReadTheDocs (http://qupath.readthedocs.io) and YouTube (https://www.youtube.com/c/qupath).

This position provides a unique opportunity to directly engage with and enhance the work of thousands of researchers. The specific focus is on improving QuPath’s core architecture and API, alongside helping the group support and train other users. It will provide opportunities to be creative and to innovate at different levels: from enhancing and optimizing the existing design (e.g. through improved parallelization), to exploring how new approaches and technologies could make the software more performant and scalable.

This job is normally based in Edinburgh, but is compatible with remote/hybrid working from within the UK.

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Research Fellow (Qualitative)

Centre: Queen's Medical Research Institute, Edinburgh, EH16 4TJ, GB

Closing Date: 24.05.22

We are looking for a Qualitative Research Fellow

Your skills and attributes for success:

  • Demonstrated ability to conduct and analyse in-depth interviews.
  • Experience of using qualitative computer software packages (Nvivo).
  • Ability to work independently under appropriate supervision.
  • Excellent project management and organisational skills.
  • Excellent personal, written and verbal communication skills.

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TestEd Quality Assurance Manager

Centre: The Centre for Genomic and Experimental Medicine (CGEM)

Closing Date: 25.05.22

The Centre for Genomic and Experimental Medicine (CGEM) uses genetics and genomics to understand the mechanisms of disease and improve disease prediction, prevention and prognosis. Our research is leading to the development of new diagnostic tests and medicines and better use of existing medicines in clinical trials.

To find out more visit https://www.ed.ac.uk/centre-genomic-medicine

The Opportunity:

The COVID-19 QAM will be a key member of the COVID-19 Testing Laboratory team and will lead on oversight of the TestEd pipeline, from sample acquisition, labelling and transport, through laboratory processes, data management and security, to confidential feedback of results to participants and customers of TestEd. The QAM will ensure that all the processes meet or exceed required quality (sensitivity, specificity etc) and will work with other members of the TestEd laboratory team and management, including the TestEd Project Manager, TestEd Quality Accreditation Manager and TestEd Operations Coordinator, to ensure the continuing smooth operation of these activities, revising and refining protocols and processes where necessary. In addition to the above duties, the QAM will maintain intimate contact with the processing of laboratory samples, contributing to the preparation of samples for RNA extraction, setup of RT-qPCR, running of PCR reactions and reporting results.

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Research Fellow/Lecturer (scientist; data analytics; deputy course organiser cancer biology; biologist)

Centre: CRUK Edinburgh Centre, Institute of Genetics and Cancer (IGC)

Closing Date: 26.05.22

We are looking for an experienced biomedical scientist with expertise and proven track record in analysis of protein pathway/proteomics/genomics data and adhesion protein and cancer biology at both experimental and computational levels. The post-holder is expected to provide basic bioinformatics/wet lab support to key research programmes in the cancer research component of Institute of Genetics and Cancer and to support teaching and student supervision. The post-holder is expected to drive biological and analytical technologies that support cancer biology programmes. He/she will take a leading role in research project(s), guided by project lead, provide intellectual and practical input into supporting other cancer biology and translational projects and contribute to and develop learning and teaching programmes.

The Opportunity:

The role includes molecular profiling of RNA, imaging, or proteins and phosphoproteins using multiple platforms including nanostring, RNAseq, mass-spectrometry-based proteomics and others where relevant, assisting with the ultimate goal of identifying novel biological hypotheses and/or protein functions and finding causal links to cancer and determining how to intervene sing wet lab technologies. A key element is to support other team members, including post-docs and PhD students. Part of this post is to teach on undergraduate courses being led from within IGC, including in cancer biology, support student project supervision and contribute to IGC’s developing postgraduate taught programmes.

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Data Support Analyst

Centre: Western General Hospital, Edinburgh, EH4 2XU, GB

Closing Date: 27/05/2022

We are looking for Data Support Analyst to join our Diabetes Informatics and Epidemiology team located at the Institute of Genetics and Cancer (IGC). The Diabetes Informatics and Epidemiology group, led by Professor Helen Colhoun conduct and facilitate research into diabetes and its complications using extensive electronic health care linked data sets including bioresources. Our analytics team comprises machine learning specialists, biostatisticians and epidemiologists. We have a reputation for excellence and many international collaborators. We are seeking a person with proven programming and data handling skills to provide a link between the source of our raw data and the analytics team.

The Opportunity:

To assist the Senior Software Developer and the Database Engineer to develop and maintain the data extraction and cleaning layers, and maintain data metadata and the associated content management system for the large research datasets of the Diabetes Informatics and Epidemiology team at IGC.

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Trial and Data Manager

Centre: MRC Human Genetics Unit, Edinburgh, EH4 2XU, GB

Closing Date: 27/05/2022

The bone research group in the Centre for Genomic and Experimental Medicine is looking for a trial and data manager. 

The Opportunity:

We are looking for an enthusiastic, resourceful and organised individual who is able to work independently, but at the same time join a multidisciplinary team. Applicants will have experience of setting-up and management of clinical studies or clinical trials including the design and maintenance of data capture systems using REDCap software and will possess good problem-solving and interpersonal skills.

The post holder will take the lead in supporting the Chief Investigator in planning, operation and management of the studies within the portfolio, including preparation of reports for funders, regulatory bodies and research ethics committees. The postholder will ensuring that the research is conducted according to Good Clinical Practice (GCP) and the Research Governance Framework.

If you have substantial experience in trial management administration and hands on experience of REDCap we would like to hear from you.

Informal enquiries may be directed to Prof Stuart H Ralston at stuart.ralston@ed.ac.uk 

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Generation Scotland Administrator

Centre: Building No. 9, Edinburgh, EH16 4UX, GB

Closing Date: 31/05/2022

We are looking for an Administrator to join the Generation Scotland team.

The Opportunity:

The post holder will be responsible for supporting projects within the Generation Scotland portfolio which is a prestigious, high profile programme and includes interdisciplinary grants in health data science. The postholder will be responsible for organising, co-ordinating and administering applications for data and/or sample access for research projects involving Generation Scotland.  This involves preparing reports, research ethics applications, supporting communications and providing ongoing administrative support to the Generation Scotland management team to develop, maintain and grow Generation Scotland. The role is the main contact point for current Generation Scotland participants and looking to join the study. The success of these tasks is critical to the success of Generation Scotland.

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Postdoctoral Researcher

Centre: Western General Hospital, Edinburgh, EH4 2XU, GB

Closing Date: 03/06/2022

We have a postdoctoral researcher opportunity available in the laboratory of Dr. Tom Deegan at the MRC Human Genetics Unit in Edinburgh.

The Opportunity:

We seek an outstanding candidate to join the group of Dr. Tom Deegan, within a programme aimed at understanding the molecular mechanisms and regulation of eukaryotic DNA replication. We have developed biochemically reconstituted systems to interrogate the ill-defined termination phase of DNA replication at the molecular level (Deegan et al, Mol. Cell., 2019; Deegan et al, eLife, 2020), and have recently described a mechanism for eukaryotic replisome disassembly (Jenkyn-Bedford et al., Nature, 2021). A number of projects are now available, using biochemical reconstitution with purified yeast and human proteins, cryo-EM, and mammalian cell models to investigate molecular mechanisms of DNA replication termination, and how this process is subverted under the types of DNA replication stress that are characteristic of human cancer. Our group is part of the MRC Human Genetics Unit, a world class centre, which provides a highly collaborative and multi-disciplinary environment within which to study eukaryotic chromosome biology.

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Research Fellow in Cellular Model Systems to Better Understand, and Prevent, Colon Cancer

Centre: MRC Human Genetics Unit, Edinburgh, EH4 2XU, GB

Closing Date: 03/06/2022

We are looking for an enthusiastic Research Fellow to join our dynamic research team at the University of Edinburgh Institute of Genetics and Cancer. We are investigating the underlying causes of Colorectal Cancer (CRC), one of the most common cancers worldwide. This post is to expand further our developments in modelling human disease through use of human and mouse tissue, as well as to develop novel genetic mouse models of cancer based on our recent discoveries of the genetic basis of the disease. The nature of our research means that we are a multi-disciplinary team, offering opportunities to develop skills in a number of disciplines, with strong links to Clinical Surgery and to Oncology.

The Opportunity:

You will join a team of researchers with a long-standing track record in colon cancer genetics, whose overarching aim is to understand the genetic and environmental cause of colorectal cancer. We aim to identify risk factors and understand the underlying mechanisms involved in order to devise novel strategies aimed at prevention of cancer and/or halting tumour progression. This post will suit an enthusiastic person to complement our work on existing and novel developments of human epithelial organoid and mouse tumour models.

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Postdoctoral Research Fellow

Centre: Western General Hospital, Edinburgh, EH4 2XU, GB

Closing Date: 07/06/2022

We are looking for an enthusiastic and highly motivated quantitative scientist, interested in applying their expertise to studying cancer genomics and evolution using cutting edge, data-driven approaches. The overall goal is to model the spatiotemporal evolutionary trajectories of structural variants in tumours to inform patient stratification, better predict treatment response and improve clinical outcome for patients.

The Opportunity:

Are you excited to develop and apply statistical and computational methods to disentangle the structural variant landscape in tumours?

This is an excellent opportunity to undertake world-class interdisciplinary science driven by clinically important questions. You will play a critical role in the statistical analyses of large cancer sequencing datasets and will be embedded in a cross-disciplinary team at the Institute of Genetics and Cancer, working collaboratively with clinicians, biologists, and other computational scientists. The position is available for 2 years, with a start date as soon as possible.

This position would suit EITHER:

  • A skilled quantitative scientist with a research background in any of maths, statistics, physics, computer science (or related disciplines) AND who is motivated to learn how to apply their skills to biomedical questions

OR

  • A computational biologist with experience analysing high-throughput genomic data, particularly from tumours.

Applicants are encouraged to contact Dr Ailith Ewing (Ailith.Ewing@ed.ac.uk) for informal enquiries.

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Please note that all vacancies are advertised on the University of Edinburgh eRecruitment website, where you can also set up personalised email notifications for future vacancies of interest.