Centre for Inflammation Research


Highlighted recent publications

Summaries of selected recent research


03/05/21 - Mitros Z, Thamo B, Bergeles C, da Cruz L, Dhaliwal K, Khadem M. Design and modelling of a continuum robot for distal lung sampling in mechanically ventilated patients in critical care. Frontiers in Robotics and AI 2021. DOI: 10.3389/frobt.2021.611866

01/06/21 - Bousquet J, Pfaar O, Agache I, et al. ARIA-EAACI care pathways for allergen immunotherapy in respiratory allergy. Clinical & Translational Allergy 2021. DOI: 10.1002/clt2.12014

02/06/21 - Marwick J, Elliott R, Longden J, Makda A, Hirani N, Dhaliwal K, Dawson JC, Carragher NO. Application of a high-content screening assay utilising primary human lung fibroblasts to identify antifibrotic drugs for rapid repurposing in COVID-19 patients. SLAS Discovery 2021. DOI: 10.1177/24725552211019405

02/06/21 - Russell CD, ISARIC4C Investigators. Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study. The Lancet Microbe 2021. DOI: 10.1016/S2666-5247(21)00090-2

04/06/21 - Suku M, Forrester LM, Biggs M, Monaghan M. Resident macrophages and their potential in cardiac tissue engineering. Tissue Engineering 2021. DOI: 10.1089/ten.TEB.2021.0036

05/06/21 - Derikx LAAP, Dolby HW, Plevris N, Lucaciu L, Rees CS, Lyons M, Siakavellas SI, Constantine-Cooke N, Jenkinson P, Su S, O'Hare C, Kirckpatrick L, Merchant LM, Noble C, Arnott ID, Jones G-R, Lees CW. Effectiveness and safety of Adalimumab Biosimilar SB5 in IBD: Outcomes in originator to SB5 switch, double biosimilar switch and bio-naieve SB5 observational cohorts. Journal of Crohn's and Colitis 2021. DOI: 10.1093/ecco-jcc/jjab100

09/06/21 - Al-omari B, McMeekin P, Allen AJ, Akram AR, Graziadio S, Suklan J, Jones WS, Lendrem BC, Winter A, Cullinan M, Gray J, Dhaliwal K, Walsh TS, Craven TH. Systematic review of studies investigating ventilator associated pneumonia diagnostics in intensive care. BMC Pulmonary Medicine 2021. DOI: 10.1186/s12890-021-01560-0

09/06/21 - Jenkins SJ, Allen JE. The expanding world of tissue resident macrophages. European Journal of Immunology 2021. DOI: 10.1002/eji.202048881

17/06/21 - Campbell RA, Docherty M, Ferenbach DA, Mylonas KJ. The role of ageing and parenchymal senescence on macrophage function and fibrosis. Frontiers in Immunology 2021. DOI: 10.3389/fimmu.2021.700790

21/06/21 - Chandrasekharan HK, McShane EP, Dhaliwal K, Thomson RR, Tanner MG. Ultrafast laser ablation of a multicore polymer optical fiber for multipoint light emission. Optics Express 2021. DOI: 10.1364/OE.424494

02/07/21 - Warner P, Whitaker LHR, Parker RA, Weir CJ, Douglas A, Holm Hansen C, Madhra M, Hillier S, Saunders PTK, Iredale JP, Semple SIK, Slayden OD, Walker BR, Critchley HOD. Low dose dexamethasone as treatment for women with heavy menstrual bleeding: a response-adaptive randomised placebo-controlled dose-finding parallel group trial (DexFEM). EBioMedicine 2021. DOI: 10.1016/j.ebiom.2021.103434

08/07/21 - COVID-19 Host Genetics Initiative, Baillie JK, Wilson JF, Bulteel N, Hayward C, Klaric L, Porteous DJ, Russell CD, Tenesa A, Norman L, Scott-Brown J, Rambaut A, Swann O. Mapping the human genetic architecture of COVID-19.  Nature 2021. DOI: 10.1038/s41586-021-03767-x

08/07/21 - O'Connor RA, Chauhan V, Mathieson L, Titmarsh H, Koppensteiner L, Young I, Tagliavini G, Dorward D, Prost S, Dhaliwal K, Wallace W, Akram AR. T cells drive negative feedback mechanisms in cancer associated fibroblasts, promoting expression of co-inhibitory ligands, CD73 and IL-27 in non-small cell lung cancer. OncoImmunology 2021. DOI: 10.1080/2162402X.2021.1940675

19/07/21 - Medina CB, Chiu Y-H, Stremska ME, Lucas CD, Poon I, Tung KS, Elliott MR, Desai B, Bayliss DA, Lorenz UM, Ravichandran KS. Pannexin 1 channels facilitate communication between T cells to restrict the severity of airway inflammation. Immunity 2021. DOI: 10.1016/j.immuni.2021.06.014

21/07/21 - Magalhaes MS, Smith P, Portman J, Jackson-Jones LH, Bain CC, Ramachandran P, Michailidou Z, Stimson RH, Dweck MR, Denby L, Henderson NC, Jenkins SJ, Benezech C. Role of Tim4 in the regulation of ABCA1+ adipose tissue macrophages and post-prandial cholesterol levels. Nature Communications 2021. DOI: 10.1038/s41467-021-24684-7

21/07/21 - Rahamn A, Mhajabin S, Dockrell DH, Nair H, El Arifeen S, Campbell H. Managing pneumonia through facility-based Integrated Management of Childhood Management (IMCI) Services: An analysis of the service availability and readiness among public health facilities in Bangladesh. BMC Health Services Research 2021. DOI: 10.1186/s12913-021-06659-y

21/07/21 - Rimmer M, Gregory CD, Mitchell RT. The transformative impact of extracellular vesicles on developing sperm. Reproduction and Fertility 2021. DOI: 10.1530/RAF-20-0076

29/07/21 - Agache I, Akdis CA, Akdis M, Brockow K, Chivato T, Giacco S, Eiwegger T, Eyerich K, Giménez‐Arnau A, Gutermuth J, Guttman‐Yassky E, Maurer M, Ogg G, Ong PY, O’Mahony L, Schwarze J, Warner A, Werfel T, Palomares O, Jutel M. EAACI Biologicals Guidelines - Omalizumab for the treatment of chronic spontaneous urticaria in adults and in the paediatric population 12–17 years old. Allergy 2021. DOI: 10.1111/all.15030

03/0821 - Islam S, Ahmed S, Roy S, Sheikh A, Cunningham S, Nair H. Operational definitions of paediatric asthma used in epidemiological studies: A systematic review. Journal of Global Health 2021. DOI: 10.7189/jogh.11.04032

06/08/21 - Russell CD, ISARIC4C Investigators. Long Covid in adults discharged from UK hospitals after Covid-19: A prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol. The Lancet Regional Health - Europe 2021. DOI: 10.1016/j.lanepe.2021.100186

10/08/21 - Bing R, Andrews J, Williams MC, van Beek EJR, Lucatelli C, MacNaught G, Clark T, Koglin N, Stephens AW, Macaskill M, Tavares AAS, Dhaliwal K, Dorward DA, Lucas CD, Dweck MR, Newby DE. In vivo thrombosis imaging in patients recovering from COVID-19 and pulmonary embolism. American Journal of Respiratory and Critical Care Medicine 2021. DOI: 10.1164/rccm.202011-4182IM

19/08/21 - Willson JA, Arienti S, Sadiku P, Reyes L, Coelho P, Morrison T, Rinaldi G, Dockrell DH, Whyt, MKB, Walmsley SR. Neutrophil HIF-1α stabilisation is augmented by mitochondrial ROS produced via the glycerol 3-phosphate shuttle. Blood 2021. DOI: 10.1182/blood.2021011010

07/09/21 - Kirkegård J, Al-Saiddi M, Bratlie SO, Coolsen M, de Haas RJ, den Dulk M, Fristrup C, Greve OJ, Harrison E, Koutouzi G, Miclea RL, Mortensen MB, Nijkamp MW, Persson J, Robertson FP, Slangen JJG, Søreide JA, Wigmore S, Mortensen FV. Intra-observer agreements in multidisciplinary team assessments of pancreatic cancer patients. Journal of Surgical Oncology 2021. DOI: 10.1002/jso.26670