Centre for Inflammation Research

Professor Manu Shankar-Hari

Manu's research programme aims to enable precision immunomodulation in critically ill adults with sepsis and acute respiratory distress syndrome (ARDS). Manu's core hypothesis is that modifiable biological networks generate clinical phenotypes and such networks could be determined by integration of clinical and immunobiology data.

Professor Manu Shankar-Hari

Chair of Translational Critical Care Medicine / Honorary Consultant in Intensive Care Medicine

Contact details

Group Members

  • Ms Jennifer Rynne - Postdoctoral Research Assistant
  • Mr Matthew Fish (PhD Student on BJA/RCoA PhD studentship) - Supervisor (Primary) with secondary supervisors based at King's College London
  • Ms Aislinn Jennings (PhD Student) - Supervisor (Primary) with secondary supervisors based at King's College London
  • Dr Rohit Saha (PhD Student) - Supervisor (Primary) with secondary supervisors based at University of Cambridge
  • Dr Julie Wilson (PhD Student) - Supervisor (Primary) with Professor Adriano G Rossi
  • Dr Ahad Abdalla (PhD Student) - Supervisor (Primary) with Professor Kev Dhaliwal

Research Overview

Critical illness is a major cause of morbidity and mortality globally. Even for the two most common critical illness syndromes - sepsis and acute respiratory distress syndrome (ARDS) - there are no effective treatments other than supportive care.

My lab pursues the hypothesis that critical illnesses reflect perturbations within intracellular and intercellular networks that link cells, and organ systems. Illness networks arise from functional interdependencies between the molecular components within human cells. Many of these illness networks are causal and determine clinical phenotypes. Thus, my lab's two focussed research themes of immunobiology and epidemiology converge to a core aim of determining these observable and treatable immunological abnormalities in critical illness (treatable traits).

The immunobiology focus of my lab are the phenotypic and molecular changes in T and B lymphocytes during critical illness and resolution from critical illness, to determine modifiable changes that could improve patient outcomes. This information is used to design seamless early to late phase human randomised clinical trials to translate immune changes into treatments for patients.

Biographical Profile

Manu Shankar-Hari trained in Intensive Care Medicine in London, completed MSc in Epidemiology from the London School of Hygiene and Tropical Medicine, and did his PhD in Immunology at the Peter Gorer Department of Immunobiology at King's College London, UK.

Manu was appointed as a consultant physician in Intensive Care Medicine at Guy's and St Thomas' Hospital NHS Foundation Trust in 2009. He was awarded the NIHR Clinician Scientist Fellowship in 2016 to investigate the long-term health consequences of sepsis survivors and to undertake a clinical trial of vaccinating to reduce long-term health care burden in adult sepsis survivors.

Manu was appointed to the Chair of Translation Critical Care Medicine at the University of Edinburgh in 2022.

Honours and Awards

  • 2019 - Lowry Fink Fellowship, International Sepsis Forum
  • 2017 - Global Rising Star in Intensive Care, Australia and New Zealand Intensive Care Society
  • 2016 - NIHR Clinician Scientist Fellowship
  • 2002 - Sanjeevani Gold Medal for best MD Student, All India Institute of Medical Sciences
  • 2001 - TJ Memorial Award for best MD Thesis, Indian Society of Anaesthesia
  • 1997 - Awarded for Best Undergraduate Student in Medicine, Trivandrum Medical College, India

Alumni

  • Dr Michael Carter, NIHR ACL (Moving to be Physicien Hospitalier, Pediatric Intensive Care, Bicetre Hospital, AP-HP Paris-Saclay University, Paris, France)
  • Dr Silvia Cellone-Trevelin, Postdoctoral Research Associate
  • Dr Yasmeen Ghnewa, Postdoctoral Research Associate
  • Dr Liang Ma, Postdoctoral Research Associate
  • Ms Carolyn Lam, Research Assistant
  • Ms Vera Peters, PhD Student

Other Responsibilities

  • Board Member, EME Funding Committee
  • Director of Research, UK Intensive Care Society
  • Associate Editor, Intensive Care Medicine
  • UK Representative, European Society of Intensive Care Medicine

Collaborators

Internal
External

Selected Publications 

1.  Writing Committee for the R-CAPI, Estcourt LJ, Turgeon AF, McQuilten ZK, McVerry BJ, Al-Beidh F, Annane D, Arabi YM, Arnold DM, Beane A, Begin P, van Bentum-Puijk W, Berry LR, Bhimani Z, Birchall JE, Bonten MJM, Bradbury CA, Brunkhorst FM, Buxton M, Callum JL, Chasse M, Cheng AC, Cove ME, Daly J, Derde L, Detry MA, De Jong M, Evans A, Fergusson DA, Fish M, Fitzgerald M, Foley C, Goossens H, Gordon AC, Gosbell IB, Green C, Haniffa R, Harvala H, Higgins AM, Hills TE, Hoad VC, Horvat C, Huang DT, Hudson CL, Ichihara N, Laing E, Lamikanra AA, Lamontagne F, Lawler PR, Linstrum K, Litton E, Lorenzi E, MacLennan S, Marshall J, McAuley DF, McDyer JF, McGlothlin A, McGuinness S, Miflin G, Montgomery S, Mouncey PR, Murthy S, Nichol A, Parke R, Parker JC, Priddee N, Purcell DFJ, Reyes LF, Richardson P, Robitaille N, Rowan KM, Rynne J, Saito H, Santos M, Saunders CT, Serpa Neto A, Seymour CW, Silversides JA, Tinmouth AA, Triulzi DJ, Turner AM, van de Veerdonk F, Walsh TS, Wood EM, Berry S, Lewis RJ, Menon DK, McArthur C, Zarychanski R, Angus DC, Webb SA, Roberts DJ, Shankar-Hari M. Effect of Convalescent Plasma on Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial. JAMA. 2021. Epub 2021/10/05. doi: 10.1001/jama.2021.18178. PubMed PMID: 34606578.

2. Gutmann C, Takov K, Burnap SA, Singh B, Ali H, Theofilatos K, Reed E, Hasman M, Nabeebaccus A, Fish M, McPhail MJ, O'Gallagher K, Schmidt LE, Cassel C, Rienks M, Yin X, Auzinger G, Napoli S, Mujib SF, Trovato F, Sanderson B, Merrick B, Niazi U, Saqi M, Dimitrakopoulou K, Fernandez-Leiro R, Braun S, Kronstein-Wiedemann R, Doores KJ, Edgeworth JD, Shah AM, Bornstein SR, Tonn T, Hayday AC, Giacca M, Shankar-Hari M, Mayr M. SARS-CoV-2 RNAemia and proteomic trajectories inform prognostication in COVID-19 patients admitted to intensive care. Nat Commun. 2021;12(1):3406. Epub 2021/06/09. doi: 10.1038/s41467-021-23494-1. PubMed PMID: 34099652; PMCID: PMC8184784.

3. Carter MJ, Fish M, Jennings A, Doores KJ, Wellman P, Seow J, Acors S, Graham C, Timms E, Kenny J, Neil S, Malim MH, Tibby SM, Shankar-Hari M. Peripheral immunophenotypes in children with multisystem inflammatory syndrome associated with SARS-CoV-2 infection. Nat Med. 2020;26(11):1701-7. Epub 2020/08/20. doi: 10.1038/s41591-020-1054-6. PubMed PMID: 32812012.

4. Laing AG, Lorenc A, Del Molino Del Barrio I, Das A, Fish M, Monin L, Munoz-Ruiz M, McKenzie DR, Hayday TS, Francos-Quijorna I, Kamdar S, Joseph M, Davies D, Davis R, Jennings A, Zlatareva I, Vantourout P, Wu Y, Sofra V, Cano F, Greco M, Theodoridis E, Freedman JD, Gee S, Chan JNE, Ryan S, Bugallo-Blanco E, Peterson P, Kisand K, Haljasmagi L, Chadli L, Moingeon P, Martinez L, Merrick B, Bisnauthsing K, Brooks K, Ibrahim MAA, Mason J, Lopez Gomez F, Babalola K, Abdul-Jawad S, Cason J, Mant C, Seow J, Graham C, Doores KJ, Di Rosa F, Edgeworth J, Shankar-Hari M, Hayday AC. A dynamic COVID-19 immune signature includes associations with poor prognosis. Nat Med. 2020;26(10):1623-35. Epub 2020/08/19. doi: 10.1038/s41591-020-1038-6. PubMed PMID: 32807934.

5. Shankar-Hari M, Phillips GS, Levy ML, Seymour CW, Liu VX, Deutschman CS, Angus DC, Rubenfeld GD, Singer M, Sepsis Definitions Task F. Developing a New Definition and Assessing New Clinical Criteria for Septic Shock: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315(8):775-87. Epub 2016/02/24. doi: 10.1001/jama.2016.0289. PubMed PMID: 26903336; PMCID: PMC4910392.

Funding

Manu's group is funded primarily by grants from the NIHR; NIHR HTA programme; MRC-EME programme; MRC; National Institute of Academic Anaesthesia; HDR UK; UKRI COVID-19 Funding

Sources of funding held in CIR :

  • NIHR HTA programme
  • MRC-EME programme
  • HDR UK