Centre for Inflammation Research

Dr Christopher Lucas

Our lab is interested in the molecular mechanisms that drive the resolution of inflammation and how these processes engage successful tissue repair after injury.

Dr Christopher Lucas

Wellcome Trust Career Development Fellow / Honorary Consultant in Respiratory Medicine

  • Centre for Inflammation Research

Contact details

Group Members

Magdalena Oremek – PhD student

Research Overview

Lung epithelial injury is the near-universal outcome of multiple pulmonary insults.  Rapid restoration of epithelial integrity prevents organ dysfunction and superadded bacterial infection, but aberrant tissue repair is a frequent and often fatal outcome in disease.  By understanding how the immune response assists with lung regeneration we aim to develop new treatments that promote lung repair after serious infection or damage.  In particular, macrophage-derived signals are critical in regeneration but these remain poorly understood.  We are investigating how macrophage-epithelial communication contributes to tissue repair and how this can be exploited therapeutically to treat disease.

Biographical Profile

I undertook medical training and a BSc (Hons) in Physiology at the University of Edinburgh.  I subsequently completed a Wellcome Trust funded PhD at the MRC Centre for Inflammation Research under the Edinburgh Clinical Academic Track (ECAT) scheme, investigating the role of immune cell apoptosis in the resolution of infection-driven lung inflammation under the supervision of Professors Adriano Rossi and Chris Haslett.  I then completed my clinical training in respiratory medicine and am currently a Wellcome Trust Clinical Career Development Fellow investigating immune cell driven lung epithelial repair after acute injury.

Honours and Awards

  • Wellcome Trust Clinical Research Career Development Fellowship, 2017
  • Scadding-Morriston-Davies Award, 2017
  • Banff International Inflammation Workshop Prize, 2017
  • Myre Sim Travel Grant, Royal College of Physicians of Edinburgh, 2016
  • Methven Prize, Scottish Thoracic Society Meeting, 2016
  • Myre Sim Award, Royal College of Physicians of Edinburgh, 2015
  • Ker Memorial Prize, Edinburgh Infectious Diseases Society, 2014
  • Myre Sim Award, Royal College of Physicians of Edinburgh, 2013
  • UK Adhesion Meeting Prize, 2013
  • Methven Prize, Scottish Thoracic Society Meeting, 2011
  • Banff International Inflammation Workshop Prize, 2011

Alumni

  • Amanda Croasdell Lucchini, Postdoctoral Researcher
  • Jennifer Felton, PhD student
  • Laura Hoodless, MSc student
  • Sidharth Sharma, BSc Hons student
  • Keith Allan, BSc Hons student
  • Mark Tait, BSc Hons student

Other Responsibilities

Honorary Consultant Respiratory Physician, Royal Infirmary of Edinburgh

Collaborators

              

Funding

  • Wellcome Trust
  • NC3Rs/BHF

Information on funding at Dr Chris Lucas' Research Explorer profile.