MRC Centre for Inflammation Research
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Professor Adam Hill

Adam Hill's group develop strategies to break the vicious cycle of infection and inflammation in bronchiectasis.

Professor Adam Hill

Consultant Physician and Honorary Professor

  • MRC Centre for Inflammation Research
  • Research Theme: Immune Modulation and Regulation of Inflammation

Contact details

Address

Street

Department of Respiratory Medicine
Royal Infirmary of Edinburgh
51 Little France Crescent

City
Edinburgh
Post Code
EH16 4SA

Group Members

  • Pallavi Mandal (PhD student)
  • Manjit Cartlidge (MD student)
  • Yang Zhang (PhD student)
  • Katarina Sing Kang (PhD student)
  • Aarjan Khanal (MSc student)
  • Sam Donadson (research nurse)
  • Andrea Clarke (research nurse)
  • Catherine Doherty (Microbiologist)

Background

There is a vicious cycle of excess neutrophilic airways inflammation and bacterial infection in patients with bronchiectasis and our research group is exploring mechanisms underpinning this and targeting therapeutic strategies.

Research Overview

Our research group have shown that both the bacterial species and bacterial load are strong drivers of neutrophilic airways and systemic inflammation. This can be reduced with short- and long-term antibiotic therapy. We are currently exploring the role of targeted antibacterial therapy in bronchiectasis. From our studies, however, the inflammatory response recurs on antibiotic cessation. We have been exploring anti-inflammatory therapies including statins and inhaled lipids (derivatives of omega-3 and omega-6 fatty acids) as potential novel therapeutic targets.

Alumni

  • Dr Maeve Smith (MD) Clinical Assistant Professor in Respiratory Medicine, University¬†of Alberta.
  • Dr James Chalmers (PhD) Discovery Fellow/Consultant, University of Dundee.

Public Engagement

A patient's guide to managing and living with Bronchiectasis

Funding

More information on funding at Adam Hill's Research Explorer profile.