Professor Adam Hill
Adam Hill's group develop strategies to break the vicious cycle of infection and inflammation in bronchiectasis.
Department of Respiratory Medicine
Royal Infirmary of Edinburgh
51 Little France Crescent
- Post Code
- EH16 4SA
- Pallavi Mandal (PhD student)
- Manjit Cartlidge (MD student)
- Yang Zhang (PhD student)
- Katarina Sing Kang (PhD student)
- Aarjan Khanal (MSc student)
- Sam Donadson (research nurse)
- Andrea Clarke (research nurse)
- Catherine Doherty (Microbiologist)
There is a vicious cycle of excess neutrophilic airways inflammation and bacterial infection in patients with bronchiectasis and our research group is exploring mechanisms underpinning this and targeting therapeutic strategies.
Our research group have shown that both the bacterial species and bacterial load are strong drivers of neutrophilic airways and systemic inflammation. This can be reduced with short- and long-term antibiotic therapy. We are currently exploring the role of targeted antibacterial therapy in bronchiectasis. From our studies, however, the inflammatory response recurs on antibiotic cessation. We have been exploring anti-inflammatory therapies including statins and inhaled lipids (derivatives of omega-3 and omega-6 fatty acids) as potential novel therapeutic targets.
- Dr Maeve Smith (MD) Clinical Assistant Professor in Respiratory Medicine, University of Alberta.
- Dr James Chalmers (PhD) Discovery Fellow/Consultant, University of Dundee.