Dr Jay Shetty
Jay Shetty's research focuses on the long term outcome in childhood epilepsy, neuro-inflammation, Central Nervous System infections and rare disease clinical trials.
Dr Jay Shetty
Consultant Paediatric Neurologist, NRS Fellow, Honorary Senior Lecturer and CLaH Module Organiser
Biography
- MB BS- Mysore Medical College, University of Mysore, India
- Research Fellow for WHO and Indian Council of Medical Research- All India Institute of Medical Sciences, New Delhi
- Paediatric Training (South East Scotland and Leeds Teaching Hospitals)
- Clinical Lecturer in Child Health-University of Dundee
- Paediatric Neurology Training (Dundee and Edinburgh)
Group Members
- Peadiatric Neurologists, Specialist Nurses and Neurophysiologists Department of Paediatric Neurosciences, Edinburgh
- Gemma Buxton, Research Fellow in Child Life and Health
- Elizabeth Pilley, Paediatric Neurology Registrar, Edinburgh.
- Libby Chatterton Dickson, Jackie Easter, Megan Hutchison, Clodagh Mitchell, Theresa Peltz, Ailidh Ramsay and Tony Yu, UG students, University of Edinburgh
Research Background
Childhood epilepsies are one of the commonest chronic neurological disorders and in Scotland there are 5000-7000 young people who are estimated to have active epilepsy. When a child is diagnosed with epilepsy the main focus is on seizure management. Apart from the seizures there are significant other factors in childhood epilepsies like learning and behavioural problems, increased incidence of psychiatric co-morbidities, risks of injuries and side effects of antiepileptic drugs, impact on quality of life, impact on future employment and risks of mortality.
My aim is to study the long term outcome of child epilepsy through routinely collected clinical data linked with imaging data, genetic data, maternity data and education data in these children.
My other area of interest is CNS infection and inflammation. I have a particular interest in enterovirus infection and outcome. Neuro-inflammatory conditions ((MS, ADEM, NMO and others) are rare in children and I am keen to explore newer treatment modalities in these conditions and study long term follow up. I am participating in number of rare disease clinical trials.
Research Overview
Currently I am involved in the following studies:
Edinburgh Paediatric Epilepsy Cohort study
Childhood epilepsy epidemiology and outcome study using routinely collected clinical data and linking with other datasets. There are a number of professionals involved in childhood epilepsy assessment, investigation, management, information provision, and managing comorbidities. The data collected routinely by different professionals are in different databases. Linking these data will be invaluable in understanding the aetiology, diagnosis and classification, planning appropriate treatment, providing accurate information, managing comorbidities and predicting long term outcome. In Scotland we have great opportunity of data linkage through Community Health Index (CHI) number, a unique individual identifier. We would like to link the epilepsy clinical datasets to other databases to explore following aspects of childhood onset epilepsy
Enterovirus CNS infection
I am involved in looking at the enterovirus CNS infection spectrum and in particular interested in EV D68 associated Acute Flaccid Paralysis. I am currently part of European Collaboration to study EV D68 infections and with Public Health England in their review of Acute Flaccid Paralysis.
Treatment of Neuro-inflammatory disorders
Clinical trials for the treatment of Paediatric Multiple Sclerosis, Encephalitis, Dyskinetic Cerebral Palsy and other rare conditions. There are limited treatment options in children with these rare conditions and I am actively participating in clinical trials with newer treatment options. I am delighted to be working with Professor Yanick Crow in providing clinical input for the future trials.
Sources of Funding
- April 2015-ongoing: NRS Fellowship. 2 sessions per week currently funded by NHS Lothian R&D and previously Chief Scientists Office, Scotland.
- 2019-2021: Teva Branded Pharmaceutical Products, R&D Inc. A Study of TEV-50717 (Deutetrabenazine) for the Treatment of Dyskinesia in Cerebral Palsy in Children and Adolescents (RECLAIM-DCP). Role: Principal Investigator
- 2015-2022: Novartis. A double-blind, randomized, multicentre, active controlled study to evaluate the safety and efficacy of fingolimod administered orally once daily versus interferon β-1a i.m. once weekly in pediatric patients with multiple sclerosis. Role: UK Chief Investigator.
- 2017-2019: Action Medical Research & RS Macdonald Charitable Trust. Investigation of sleep quality and prevalence of sleep-disordered breathing in children and young people with epilepsy. Role: Co-Investigator.
- 2016-2019: NIHR. A phase III multi-centre randomised, double blind, placebo controlled trial to assess the role of intravenous immunoglobulin in the management of children with encephalitis (The IgNiTE study). Role: Principle Investigator.
- 2014-2018: Epilepsy Research UK. The Genetic and Autoimmune Causes of Childhood Epilepsy (GACE) study. Role: Co-Investigator.
Publications
Symonds JD, Zuberi SM, Stewart K, McLellan A, O'Regan M, MacLeod S, Jollands A, Joss S, Kirkpatrick M5, Brunklaus A, Pilz DT, Shetty J, Dorris L, Abu-Arafeh I, Andrew J, Brink P, Callaghan M, Cruden J, Diver LA, Findlay C, Gardiner S, Grattan R, Lang B, MacDonnell J, McKnight J, Morrison CA, Nairn L, Slean MM, Stephen E, Webb A, Vincent A, Wilson M. Incidence and phenotypes of childhood-onset genetic epilepsies: a prospective population-based national cohort. Brain. 2019, 142(8):2303-2318.
Crow YJ, Shetty J, Livingston JH. Treatments in Aicardi-Goutières syndrome. Dev Med Child Neurol. 2019, Jun 7.
Hunter MB, Yoong M, Sumpter RE, Verity K, Shetty J, McLellan A, Jones J, Quigley A, Tallur KK, Chin RFM. Neurobehavioral problems in children with early-onset epilepsy: A population-based study. Epilepsy Behav. 2019, 93:87-93.
Shetty J, Kandasamy J, Sokol D, Gallo P. Clinical deterioration despite syringomyelia resolution after successful foramen magnum decompression for Chiari malformation - Case series. Eur J Paediatr Neurol. 2019, 23(2):333-337.
Kirolos A, Mark K, Shetty J, Chinchankar N, Mcdougall C, Eunson P, Stevenson J, Templeton K; NHS Lothian EV-D68 Associated AFM Study Group. Outcome of paediatric acute flaccid myelitis associated with enterovirus D68: a case series. Dev Med Child Neurol. 2019, 61(3):376-380.
Kramer R, Lina B, Shetty J. Acute flaccid myelitis caused by enterovirus D68: Case definitions for use in clinical practice. Eur J Paediatr Neurol. 2019, 23(2):235-239.
Kinney-Lang E, Yoong M, Hunter M, Kamath Tallur K, Shetty J, McLellan A, Fm Chin R, Escudero J. Analysis of EEG networks and their correlation with cognitive impairment in preschool children with epilepsy. Epilepsy Behav. 2019, 90:45-56.
Knoester M, Helfferich J, Poelman R, Van Leer-Buter C, Brouwer OF, Niesters HGM; 2016 EV-D68 AFM Working Group. Twenty-nine Cases of Enterovirus-D68-associated Acute Flaccid Myelitis in Europe 2016: A Case Series and Epidemiologic Overview. Pediatr Infect Dis J. 2019, 38(1):16-21.
Chitnis T, Arnold DL, Banwell B, Brück W, Ghezzi A, Giovannoni G, Greenberg B, Krupp L, Rostásy K, Tardieu M, Waubant E, Wolinsky JS, Bar-Or A, Stites T, Chen Y, Putzki N, Merschhemke M, Gärtner J; PARADIGMS Study Group. Trial of Fingolimod versus Interferon Beta-1a in Pediatric Multiple Sclerosis. N Engl J Med. 2018, 379(11):1017-1027.
Emelifeonwu JA, Shetty J, Kaliaperumal C, Gallo P, Sokol D, Soleiman H, Kandasamy J. Acute Cerebellitis in Children: A Variable Clinical Entity. J Child Neurol. 2018, 33(10):675-684.
Yoong M, Hunter M, Stephen J, Quigley A, Jones J, Shetty J, McLellan A, Bastin ME, Chin RFM. Cognitive impairment in early onset epilepsy is associated with reduced left thalamic volume. Epilepsy Behav. 2018, 80:266-271.
Shetty J, Greene SA, Mesalles-Naranjo O, Kirkpatrick M. Adherence to antiepileptic drugs in children with epilepsy in a Scottish population cohort. Dev Med Child Neurol. 2016, 58(5):469-74.
Shetty J. Neonatal seizures in hypoxic-ischaemic encephalopathy--risks and benefits of anticonvulsant therapy. Dev Med Child Neurol. 2015, 57 Suppl 3:40-3.
Shetty J, Fraser J, Goudie D, Kirkpatrick M. Aicardi syndrome in a 47 XXY male - a variable developmental phenotype? Eur J Paediatr Neurol. 2014,18(4):529-31.
de Vries B, Stam AH, Kirkpatrick M, Vanmolkot KR, Koenderink JB, van den Heuvel JJ, Stunnenberg B, Goudie D, Shetty J, Jain V, van Vark J, Terwindt GM, Frants RR, Haan J, van den Maagdenberg AM, Ferrari MD. Familial hemiplegic migraine is associated with febrile seizures in an FHM2 family with a novel de novo ATP1A2 mutation. Epilepsia. 2009, 50(11):2503-4.
Honours and Awards
- Indian Council of Medical Research Student Fellowship
- Next Generation Clinical Academic Role Model award by BMA
Public Engagement Activities
- Epilepsy Education through Scottish Paediatric Epilepsy Network
Other Responsibilities
- Undergraduate Module Lead - Child Life and Health, University of Edinburgh
- Supervision of undergraduate and postgraduate research projects
- Scottish Paediatric Epilepsy Surgery Team
- Chair, SIGN Guideline for Paediatric Epilepsy
- Connect4children(c4c): Neuroscience and Epilepsy Expert Group
Collaborators
- Professor Yanick Crow, Edinburgh
- Dr Catherine McDougall, Edinburgh
- Dr Don Urquhart, Edinburgh
- Dr Chin, Muir Maxwell Epilepsy Centre
- Professor Martin Kirkpatrick, Dundee