Infection Medicine

Dr Mariela Scortti

Principal Investigator

Dr Mariela Scortti

Principal Investigator

  • The Chancellor's Building
  • 49 Little France Crescent, Edinburgh
  • EH16 4SB

Contact details

Personal Profile

Mariela has a degree in Veterinary Medicine from the Universidad del Litoral (Argentina, 1990) and a MSc in Veterinary Epidemiology from the Universidad de Chile (Chile, 1996). She later moved to Madrid to investigate animal vaccinology and obtained a PhD from Universidad Complutense de Madrid (Spain, 2000). Mariela joined the group of Prof Vazquez-Boland in 2001, working initially at the University of Leon (Spain) and later at the University of Bristol (2002-2007) and currently at the University of Edinburgh. Her work currently focuses on the molecular determinants of bacterial virulence.

Research Theme

Recent Publications

  1. Lourenço, A., de Las Heras, A., Scortti, M., Vazquez-Boland, J., Frank, J.F., Brito, L. (2013) Comparison of Listeria monocytogenes Exoproteomes from biofilm and planktonic state: Lmo2504, a protein associated with biofilms. Appl Environ Microbiol. 79:6075-82.
  2. Salifu SP, Valero-Rello A, Campbell SA, Inglis NF, Scortti M, Foley S, Vázquez-Boland JA. (2013) Genome and proteome analysis of phage E3 infecting the soil-borne actinomycete Rhodococcus equi. Environ Microbiol Rep. 5:170-8.
  3. Deshayes C., Bielecka M.K., Cain R.J., Scortti M., de Las Heras A., Pietras Z., Luisi B.F., Núñez Miguel R., Vazquez-Boland J.A. (2012) Allosteric mutants show that PrfA activation is dispensable for vacuole escape but required for efficient spread and Listeria survival in vivo. Mol. Microbiol. 85: 461-477.
  4. Buchrieser, C., Rusniok, C., Garrido, P., Hain, T., Scortti, M., Lampidis, R., Kärst, U., Chakraborty, T.,Cossart, P., Kreft, J., Vazquez-Boland, J.A., Goebel, W., Glaser, P. (2011) Complete genome sequence of the animal pathogen Listeria ivanovii, which provides insights into host specificities and evolution of the genus Listeria. J Bacteriol. 193:6787-8
  5. Letek, M., Gonzalez, P., MacArthur I., Rodriguez, H., Freeman,T.C, Valero-Rello,A., Blanco, M., Buckley, T., Cheverach, I., Fahey, R., Hapeshi, A., Holdstock, J., Leadon, D., Navas, J., Ocampo, A., Quail, M.A., Sanders, M., Scortti, M., Prescott, J.F., Fogarty, U., Meijer, W.G., Parkhill, J., Bentley, S.D., Vazquez-Boland, J.A. (2010). The genome of a pathogenic Rhodococcus: cooptive virulence underpinned by key gene acquisitions. PLoS Genet. 6:e1001145.
  6. Ocampo-Sosa, A.A., Lewis, D.A., Navas, J., Quigley, F., Callejo, R., Scortti, M., Fogarty, U., Vazquez-Boland, J.A. (2007) Molecular epidemiology of Rhodococcus equi based on traA, vapA and vapB plasmid markers. J. Infect. Dis. 196: 763-769.
  7. Scortti, M., Lacharme-Lora, L., Wagner, M., Chico-Calero, I., Losito, P., Vazquez-Boland, J.A. (2006) Coexpression of virulence and fosfomycin susceptibility in Listeria: molecular basis of an antimicrobial in vitro- in vivo paradox. Nat. Med. 12: 515-517.
  8. Dominguez-Bernal, G. Muller-Altrock, S., Gonzalez-Zorn, B., Scortti, M., Herrmann, P., Monzo, H.J., Lacharme-Lora, L., Kreft , J., Vazquez-Boland, J.A. (2006) A spontaneous genomic deletion in Listeria ivanovii identifies LIPI-2, a species-specific pathogenicity island encoding sphingomyelinase and numerous internalins. Mol. Microbiol. 59: 415-432
  9. Ermolaeva, E.; Novella, S.; Vega, Y., Ripio, M.T.; Scortti, M.; Vazquez-Boland, J.A. (2004) Negative control of Listeria monocytogenes virulence genes by a diffusible autorepressor. Mol. Microbiol. 52: 601-611.
  10. Chico-Calero, I., Suarez, M., Gonzalez-Zorn, B., Scortti, M., Slaghuis, J., Vazquez-Boland, J.A. (2002) Hpt, a bacterial homolog of the microsomal glucose-6-phosphate translocase, mediates rapid intracellular proliferation in Listeria. PNAS 99: 431-436.