Dr. Juan-Carlos Jiménez-Castellanos
I am committed to a research career in the basic biological science/medicine interface – I enjoy unraveling the molecular details of complex biological systems with the ultimate aim of helping to develop new medicines
- D.Phil in Cellular and Molecular Medicine. University of Bristol. 2017.
- Research Coordinator at the Molecular Microbiology Laboratory head by Professor Fernando Montiel, M.D; D. Phil. School of Chemistry. National Autonomous University of Mexico (UNAM) 09/2009-12/2013.
- Technical supervisor at the Molecular Microbiology Laboratory head by Professor Fernando Montiel, M.D; D. Phil. School of Chemistry. National Autonomous University of Mexico (UNAM) 08/2008-07/2009.
- Bachelor degree. Chemical-Pharmaceutical-Biologist, Faculty of Chemistry, UNAM.
My current work is leading to a better understanding of multidrug-resistance in key human pathogens, particularly carbapenem resistant enteric bacteria (e.g. Klebsiella pneumoniae), which are first on the list of key multidrug-resistant threats recently published by the World Health Organisation.
Specifically, I am interested in:
-The control of RND-type multidrug efflux pump systems, and how these regulators perform a global role to control antibiotic permeability across the envelope.
-The development on biofilm formation mediated by a loss of function in permeability across the envelope.
-The molecular mechanisms and evolution on antibiotic resistance.
-The combination/interaction between efflux pumps and β-lactamases for β-lactam resistance, particularly carbapenem resistance in enteric bacteria
I enjoy being involved in inter-disciplinary work that can led to the development of new scaffolds of inhibitors against AMR.
- Juan-Carlos Jiménez-Castellanos, Wan Nur Ismah Wan Ahmad Kamil, Ching Hei Phoebe Cheung, Maryann S. Tobin, James Brown, Sophie G. Isaac, Kate J. Heesom, Thamarai Schneiders and Matthew B. Avison. Comparative effects of overproducing the AraC-type transcriptional regulators MarA, SoxS, RarA and RamA on antimicrobial drug susceptibility in Klebsiella pneumoniae. Journal of Antimicrobial Chemotherapy. 2016. DOI:10.1093/jac/dkw088.
- Juan-Carlos Jiménez-Castellanos, Wan Ahmad Kamil Wan Nur Ismah, Yuiko Takebayshi, Jacqueline Findlay, Thamarai Schneiders, Kate J. Heesom & Matthew B. Avison. The Envelope Proteome Changes Driven by RamA Overproduction in Klebsiella pneumoniae that Enhance Acquired β-Lactam Resistance. Journal of Antimicrobial Chemotherapy. 2017. doi: https://doi.org/10.1101/133918.
- Juan-Carlos Jiménez-Castellanos. THE BATTLE AGAINST ANTIBIOTIC RESISTANCE. Personal Communication. Mini article. Bristol Magazine; July. 2017.
- Jürgen Brem, Ricky Cain, Samuel Cahill, Michael A. McDonough, Ian J. Clifton, Juan-Carlos Jiménez-Castellanos, Matthew B. Avison, James Spencer, Colin W.G. Fishwick & Christopher J. Schofield. Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates. Nature Communications. 2016. DOI: 10.1038/ncomms12406
- Guo-Bo Li, Jürgen Brem, Robert Lesniak, Martine I. Abboud, Christopher T. Lohans, Ian J. Clifton, Sheng-Yong Yang, Juan-Carlos Jiménez-Castellanos, Matthew B. Avison, James Spencer, et al. Crystallographic Analyses Reveal a New Mode of Metallo-β-Lactamase Inhibition.
Chemical Communications. 2017. DOI: 10.1039/C7CC02394D
- Wan Ahmed Kamil Wan Nur Ismah, Yuiko Takebayashi, Jacqueline Findlay, Kate J Heesom, Juan-Carlos Jimenez-Castellanos, Jay Zhang, Lee Graham, Karen Bowker, Martin Williams, Alasdair P MacGowan, Matthew B Avison. Prediction of fluoroquinolone susceptibility directly from whole genome sequence data using liquid chromatography-tandem mass spectrometry to identify mutant genotypes. 2018 doi: https://doi.org/10.1101/138248
- Juan-Carlos Jiménez-Castellanos, Raquel Ortega, and Fernando Montiel. Multidrug-Resistant Bacteria from Normal Skin of Healthy Young Individuals from México City. Preprint. 2018.