MRC Institute of Genetics & Molecular Medicine
MRC Institute of Genetics & Molecular Medicine

Vacancies

Current vacancies within the IGMM.

A summary of current IGMM vacancies is provided below. Queries can be directed to the contact provided within the job vacancy or email IGMM Human Resources: IGMMHR@igmm.ed.ac.uk

Please note that all IGMM vacancies are advertised on the University of Edinburgh eRecruitment website, where you can also set up personalised email notifications for future vacancies of interest.

Research Fellow in Developmental Genetics (Vacancy Ref: 051788)

Centre Name: MRC Human Genetics Unit at the University of Edinburgh

Closing date: 9 April 2020

Overview:

Applications are invited for a three-year postdoctoral research position in the group of Prof Wendy Bickmore at the MRC Human Genetics Unit, University of Edinburgh.

We are looking for a postdoc to work to join an exciting new BBSRC/NSF funded project to systematically investigate the role of cis-regulatory sequences (enhancers) in development and disease. This project will focus on establishing a platform for systematically answering fundamental questions about how developmental systems are wired in our genome employing a synthetic genomics-based approach called ‘synthetic hypervariation’. The locus under investigation is the regulatory landscape surrounding a key gene involved in eye development, PAX6. The postholder would actively collaborate with the laboratory of Prof. Jef Boeke (New York University) in redesigning the human PAX6 locus. On the experimental side the project will involve two main objectives. First the postholder would generate zebrafish transgenic lines harbouring the redesigned human PAX6 locus using a combination of genome recombineering and genome editing experiments in zebrafish, followed by characterisation of these lines by live imaging experiments. The second objective would be replacing the mouse PAX6 locus with the re-engineered human PAX6 locus in mouse embryonic stem cells. These cells would be tested in mouse optic cup organoid differentiation systems to assay the capabilities of re-engineered regulatory landscapes.

Applicants should have, or be soon-to-be-awarded, a PhD in relevant area of genetics, molecular or developmental biology. The candidate should have sound understanding of transcriptional regulation and experience with a broad range of molecular biology/cell biology techniques. Candidates should have excellent verbal and written communication skills, and the ability to work well as part of a group.

Candidates are strongly encouraged to contact Prof. Wendy Bickmore at wendy.bickmore@igmm.ed.ac.uk or Dr. Shipra Bhatia at Shipra.bhatia@igmm.ed.ac.uk to discuss the post in more detail.

Salary: £33,797 - £40,322

Further information