The SCOTTY Study: Sequencing of Colon Trios in the Young
The SCOTTY Study: Sequencing of Colon Trios in the Young

The SCOTTY study

The SCOTTY Study is a major initiative to conduct “next generation sequencing” of the whole genome of young colon cancer patients and both parents where there is no evidence of cancer running in the family. This will, in the long term, help us to develop new treatments and predict who will be susceptible to cancer and so be able to prevent disease progression.

Study summary

Our aim in this study is to conduct detailed genetic analysis of blood and tissue removed from tumours from individuals who have developed bowel cancer at a young age and also blood samples from each of their parents.

Aims & objectives

By conducting next generation sequencing of the whole genome of young colon cancer patients and both parents, we aim to identify new mutations arising in affected patients and recessive genetic traits where one rare allele is inherited from each unaffected parent.