MRC Institute of Genetics & Molecular Medicine
MRC Institute of Genetics & Molecular Medicine

Animal models

Dedicated facilities ensuring animal welfare and the principles of Replacement, Reduction and Refinement are applied in every area of our animal research.

Many of the medical breakthroughs we take for granted today – including vaccines, antibiotics, painkillers, asthma inhalers and cancer drugs – would not have been possible without research involving animals.

IGMM scientists use a wide range of non-animal experimental technologies including computer simulations, medical imaging and growing cells and tissues in the laboratory. However, some studies can only be undertaken in a whole animal, for example, when developing potential new medicines for diseases such as cancer, or investigating how genetic mutations affect multiple organs and processes within the body.

All research involving animals is regulated under the Animals (Scientific Procedures) Act. IGMM Researchers are supported by dedicated facilities that ensure animal welfare and the principles of the three ‘Rs’ – Replacement, Reduction and Refinement - are applied in every area of our animal research.

Zebrafish facility

zebrafish

The Zebrafish Facility exists to support world class research using the exciting, rapidly growing model organism that is the zebrafish. The facility maintains a wide array of zebrafish lines encompassing the model’s impressive and flexible genetic toolbox.

As well as providing excellent daily care and animal husbandry, we offer scientific expertise to assist with planning, implementation and troubleshooting of zebrafish experiments. This support extends to practical assistance with training and carrying out one-off experiments.

Our expertise is focused on, but not limited to, supporting the use of zebrafish as a model organism for studying developmental genetics and biomedical research, with modern imaging as a central technique.

In addition to working with zebrafish focused labs, we encourage and support labs who may find zebrafish suitable for answering specific questions but have no prior zebrafish experience. The promotion of the use of zebrafish marries our dedication to facilitating the highest quality research with our strong commitment to the 3Rs, particularly in terms of replacement.

Contact

For more information on the services provided within the facility, please contact:

ZFManager@ed.ac.uk

Central Bio-research Services (CBS) Transgenic Core

IGMM Transgenics & embryonic stem cell technologies

The CBS Transgenic Core (CTC) offers a comprehensive, reliable & high-quality transgenic service to researchers at the University of Edinburgh.

CTC specializes in the production of transgenic rodents through microinjection of DNA, RNA or Embryonic Stem (ES) cells. The evolution of CRISPR/CAS9 technology has revolutionized the field of transgenesis and, in collaboration with the researchers at the University, we have used this technology with great success to produce knock-out and knock-in rodent mice. 

Other services offered by CTC include Cryopreservation of sperm and embryos and Rederivation of rodent lines via embryo transfer, IVF or Intracytoplasmic Sperm Injection (ICSI).

Contact

For more information about the services offered by the facility, or to receive a job-specific quote, please visit:

www.ed.ac.uk/bioresearch-services/transgenics