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Bid to beat drug resistance boosted by worldwide sewage survey

Efforts to monitor the spread of antibiotic resistance worldwide could be transformed with a map created using data from analysis of sewage samples.

Worldwide distribution of AMR in bacteria
Levels of antimicrobial resistance are highest across large areas of the developing world. Image courtesy of Frank Aarestrup, Technical University of Denmark.

An international team of scientists analysed the DNA of antibiotic-resistant bacteria found in samples gathered from more than 60 countries.

Their method offers a relatively inexpensive, fast and simple way to track drug resistance in human populations.

Higher levels of drug resistance genes were found in South America, Asia and Africa compared with developed regions such as North America and Europe.

Improving sanitation is key

Improved health and sanitation could potentially limit the global burden of resistance to antibiotics, scientists say.

Analysis of the results alongside existing data on countries’ health and development enabled scientists to predict drug resistance in regions not included in sewage sampling.

The wealth of information gathered in the study – some 10 billion individual measurements – could also enable research into other aspects of health, such as the global spread of viruses.

Sewage sampling
Tamale in Ghana is just one of 60 sites where the antimicrobial resistance of bacteria in sewage is being analysed. Image courtesy of Courage Kosi Setsoafia Saba, University of Development Studies, Ghana.

Game-changing study

The team is to continue sampling twice-yearly until 2022, allowing scientists to map health trends over time. It could help spot trends in disease spread or identify emerging worldwide infections.

The study, published in Nature Communications, was led by the Technical University of Denmark in collaboration with the University of Edinburgh and researchers in the Netherlands. It was supported by the European Union Horizon 2020 programme and the World Health Organization.

Professor Mark Woolhouse, of the University of Edinburgh’s Usher Institute, who took part in the study, said:

We believe that this new approach to surveillance of antimicrobial resistance around the world is a game-changer, making the difficult task of monitoring this threat far easier than before.

More information

For more information please contact:

Catriona Kelly, Press & PR Office, 0131 651 4401; 07791 355940; Catriona.Kelly@ed.ac.uk

Related Links

Antimicrobial Resistance research at the University of Edinburgh

Usher Institute of Population Health Sciences and Informatics

Technical University of Denmark genomic epidemiology group