UK launches £20m whole genome sequence alliance to map spread of coronavirus
A team of academics at the University of Edinburgh and NHS Lothian are part of national consortium that will look for breakthroughs that help the UK respond to this and future pandemics, and save lives.
The Government and the UK’s Chief Scientific Adviser have backed the UK’s leading clinicians and scientists to map how COVID-19 spreads and behaves by using whole genome sequencing.
COVID-19 Genomics UK Consortium - comprised of the NHS, Public Health Agencies, Wellcome Sanger Institute, and a numerous academic institutions including the University of Edinburgh - will deliver large scale, rapid sequencing of the cause of the disease and share intelligence with hospitals, regional NHS centres and the Government.
The team in Edinburgh is led by Prof Andrew Rambaut in the School of Biological Sciences, and involves staff in NHS Lothian.
Network of sequencing centres
Samples from patients with confirmed cases of COVID-19 will be sent to a network of sequencing centres which currently includes Belfast, Birmingham, Cambridge, Cardiff, Edinburgh, Exeter, Glasgow, Liverpool, London, Norwich, Nottingham, Oxford and Sheffield.
The Wellcome Sanger Institute, one of the world’s most advanced centres of genomes and data, will collaborate with expert groups across the country to analyse the genetic code of COVID-19 samples circulating in the UK and in doing so, give public health agencies and clinicians a unique, cutting-edge tool to combat the virus.
Improving clinical care and control
By looking at the whole virus genome in people who have had confirmed cases of COVID-19, scientists can monitor changes in the virus at a national scale to understand how the virus is spreading and whether different strains are emerging. This will help clinical care of patients and save lives.
The UK Consortium, supported by the Government, including the NHS, Public Health England, UK Research and Innovation (UKRI), and Wellcome, will enable clinicians and public health teams to rapidly investigate clusters of cases in hospitals, care homes and the community, to understand how the virus is spread and implement appropriate infection control measures.
This new investment and the findings from the consortium will help prepare the UK and the world for future pandemics.
“At a critical moment in history, this new consortium will bring together the UK’s brightest and best scientists to build our understanding of this pandemic, tackle the disease and ultimately, save lives. “As a Government we are working tirelessly to do all we can to fight COVID-19 to protect as many lives and save as many jobs as possible.”
“Genomic sequencing will help us understand COVID-19 and its spread. It can also help guide treatments in the future and see the impact of interventions. “The UK is one of the world’s leading destinations for genomics research and development, and I am confident that our best minds, working as part of this consortium, will make vital breakthroughs to help us tackle this disease.”
“This virus is one of the biggest threats our nation has faced in recent times and crucial to helping us fight it is understanding how it is spreading. Harnessing innovative genome technologies will help us tease apart the complex picture of coronavirus spread in the UK, and rapidly evaluate ways to reduce the impact of this disease on our society.”
“In response to the ongoing COVID-19 pandemic, the Sanger Institute will deploy its large-scale sequencing platform alongside regional sequencing centres to support UK Public Health Agencies, regional NHS centres and several Universities to better understand the coronavirus outbreak in the UK. “Samples from substantial numbers of confirmed cases of COVID-19 will be whole genome sequenced and, employing the Sanger Institute’s expertise in genomics and surveillance of infectious diseases, our researchers will collaborate with other leading groups across the country to analyse the data generated and work out how coronavirus is spreading in the UK. This will inform national and international strategies to control the pandemic and prevent further spread.”
“By bringing together public health expertise from Public Health England and genomic science from the Wellcome Sanger Institute the UK can crack the code of this virus, and we should give everyone involved huge credit for that. “Rapid genome sequencing of COVID-19 will give us unparalleled insights into the spread, distribution and scale of the epidemic in the UK. The power of 21st century science to combat this pandemic is something that those going before us could not have dreamt of, and it is incumbent on us to do everything we can to first understand, and then limit, the impact of COVID-19.”
“The UK is a leader in cutting edge genome sequencing science. We are now applying specialist expertise in our fight to slow the spread of Coronavirus and accelerate treatments for those affected. “The ambitious and coordinated response of our research community to the COVID-19 challenge is remarkable.”
School of Biological Sciences, University of Edinburgh