Congratulations to Edinburgh Infectious Diseases members on excellent publications in autumn 2018!

Researchers from across Edinburgh Infectious Diseases have published a dazzling array pf papers in the past months - take a browse through some of the highlights here!

Tsetse fly on a stick — Papers cover neglected tropical diseases and antimicrobial resistance to calls for global action on pneumonia.

A gene expression comparison of Trypanosoma brucei and Trypanosoma congolense in the bloodstream of the mammalian host

Silvester E, Ivens A, Matthews KR. PLoS Negl Trop Dis. 2018 Oct 11;12(10):e0006863. doi: 10.1371/journal.pntd.0006863

Adaptive plasticity in the gametocyte conversion rate of malaria parasites

Schneider P, Greischar MA, Birget PLG, Repton C, Mideo N, Reece SE. PLoS Pathog. 2018 Nov 14;14(11):e1007371. doi: 10.1371/journal.ppat.1007371

Antigenic and sequence variability of the human respiratory syncytial virus F glycoprotein compared to related viruses in a comprehensive dataset

Mas V, Nair H, Campbell H, Melero JA, Williams TC. Vaccine. 2018 Oct 29;36(45):6660-6673. doi: 10.1016/j.vaccine.2018.09.056

Antiviral activity of the mineralocorticoid receptor NR3C2 against Herpes simplex virus Type 1 (HSV-1) infection

Haas JG, Weber J, Gonzalez O, Zimmer R, Griffiths SJ. Sci Rep. 2018 Oct 26;8(1):15876. doi: 10.1038/s41598-018-34241-w

Antiviral innate immune response in non-myeloid cells is augmented by chloride ions via an increase in intracellular hypochlorous acid levels

Ramalingam S, Cai B3, Wong J, Twomey M, Chen R, Fu RM, Boote T, McCaughan H, Griffiths SJ, Haas JG. Sci Rep. 2018 Sep 11;8(1):13630. doi: 10.1038/s41598-018-31936-y

Bovine Staphylococcus aureus Superantigens Stimulate the Entire T Cell Repertoire of Cattle

Wilson GJ, Tuffs SW, Wee BA, Seo KS, Park N, Connelley T, Guinane CM, Morrison WI, Fitzgerald JR. Infect Immun. 2018 Oct 25;86(11). pii: e00505-18. doi: 10.1128/IAI.00505-18

Characterisation of the British honey bee metagenome

Regan T, Barnett MW, Laetsch DR, Bush SJ, Wragg D, et al, Nat Commun. 2018 Nov 26;9(1):4995. doi: 10.1038/s41467-018-07426-0

Coinfections and comorbidities in African health systems: At the interface of infectious and noninfectious diseases

Osakunor DNM, Sengeh DM, Mutapi, F; PLoS Negl Trop Dis. 2018 Sep 20;12(9):e0006711. doi: 10.1371/journal.pntd.0006711

Comparative genomics of the major parasitic worms

International Helminth Genomes Consortium; Nat Genet. 2018 Nov 5. doi: 10.1038/s41588-018-0262-1

Concerted IL-25R and IL-4Rα signaling drive innate type 2 effector immunity for optimal helminth expulsion

Smith KA1, Löser S, Varyani F, Harcus Y, McSorley HJ, McKenzie AN, Maizels RM. Elife. 2018 Sep 21;7. pii: e38269. doi: 10.7554/eLife.38269

Crispr/Cas Mediated Deletion of PTPN22 in Jurkat T Cells Enhances TCR Signaling and Production of IL-2

Bray C, Wright D, Haupt S, Thomas S, Stauss H, Zamoyska R. Front Immunol. 2018 Nov 12;9:2595. doi: 10.3389/fimmu.2018.02595

Cytokine and Chemokine Concentrations as Biomarkers of Feline Mycobacteriosis

O'Halloran C, McCulloch L, Rentoul L, Alexander J, Hope JC, Gunn-Moore DA. Sci Rep. 2018 Nov 23;8(1):17314. doi: 10.1038/s41598-018-35571-5

Delayed neutrophil apoptosis enhances NET formation in cystic fibrosis

Gray RD, Hardisty G, Regan KH, Smith M, Robb CT, Duffin R, Mackellar A, et al. Thorax. 2018 Feb;73(2):134-144. doi: 10.1136/thoraxjnl-2017-210134

Development of superficial lung lesions monitored on farm by serial ultrasonographic examination in sheep with lesions confirmed as ovine pulmonary adenocarcinoma at necropsy

Scott PR, Dagleish MP, Cousens C. Ir Vet J. 2018 Nov 5;71:23. doi: 10.1186/s13620-018-0134-0

Developmental roadmap for antimicrobial susceptibility testing systems

van Belkum A1, Bachmann TT, et al, and the Group on Antimicrobial Resistance and Rapid Diagnostic Testing; Nat Rev Microbiol. 2018 Oct 17. doi: 10.1038/s41579-018-0098-9

Drug Target Selection for Trypanosoma cruzi Metabolism by Metabolic Control Analysis and Kinetic Modeling

Saavedra E, Gonzalez-Chavez Z, Moreno-Sanchez R, Michels PAM; Curr Med Chem. 2018 Sep 16. doi: 10.2174/0929867325666180917104242

Evidence of a distinct group of Black African patients with systemic lupus erythematosus

Sibanda EN, Chase-Topping M, Pfavayi LT, Woolhouse MEJ, Mutapi F. BMJ Glob Health. 2018 Sep 16;3(5):e000697. doi: 10.1136/bmjgh-2017-000697. eCollection 2018

Exploring the effect of human and animal population growth on vector-borne disease transmission with an agent-based model of Rhodesian human African trypanosomiasis in eastern province, Zambia

Alderton S, Macleod ET, Anderson NE, Machila N, Simuunza M, Welburn SC; Atkinson PM1; PLoS Negl Trop Dis. 2018 Nov 8;12(11):e0006905. doi: 10.1371/journal.pntd.0006905

Fogarty International Center collaborative networks in infectious disease modeling: Lessons learnt in research and capacity building

Nelson MI, Lloyd-Smith JO, Simonsen L, Rambaut A, et al; . Epidemics. 2018 Oct 23. pii: S1755-4365(18)30029-X. doi: 10.1016/j.epidem.2018.10.004

Gene silencing by RNA interference in the ectoparasitic mite, Psoroptes ovis

Marr EJ, Wright HW, Sargison ND, Nisbet AJ, Burgess STG4 Vet Res. 2018 Nov 1;49(1):112. doi: 10.1186/s13567-018-0608-9

Generation of Markerless Deletions in the Nosocomial Pathogen Clostridium difficile by induction of DNA Double-strand Breaks

Theophilou ES, Vohra P, Gallagher MP, Poxton IR, Blakely GW. Appl Environ Microbiol. 2018 Nov 26. pii: AEM.02055-18. doi: 10.1128/AEM.02055-18

Genome hypermobility by lateral transduction

Chen J, Quiles-Puchalt N, Chiang YN, Bacigalupe R, Fillol-Salom A, Chee MSJ, Fitzgerald JR, Penadés JR5. Science. 2018 Oct 12;362(6411):207-212. doi: 10.1126/science.aat5867

Giardia duodenalis in the UK: current knowledge of risk factors and public health implications

Horton B, Bridle H, Alexander CL, Katzer F. Parasitology. 2018 Oct 15:1-12. doi: 10.1017/S0031182018001683

Global, regional, and national estimates of pneumonia morbidity and mortality in children younger than 5 years between 2000 and 2015: a systematic analysis

McAllister DA, Liu L, Shi T, Chu Y, Reed C, Burrows J, Adeloye D, Rudan I, Black RE, Campbell H, Nair H. Lancet Glob Health. 2018 Nov 26. pii: S2214-109X(18)30408-X. doi: 10.1016/S2214-109X(18)30408-X

Impact of Genetic Selection for Increased Cattle Resistance to Bovine Tuberculosis on Disease Transmission Dynamics

Raphaka K, Sánchez-Molano E, Tsairidou S, Anacleto O, Glass EJ, Woolliams JA, Doeschl-Wilson A, Banos G1; Front Vet Sci. 2018 Oct 1;5:237. doi: 10.3389/fvets.2018.00237

In situ identification of Gram-negative bacteria in human lungs using a topical fluorescent peptide targeting lipid A

Akram AR, Chankeshwara SV, Scholefield E, Aslam T, McDonald N, Megia-Fernandez A, et al; Sci Transl Med. 2018 Oct 24;10(464). pii: eaal0033. doi: 10.1126/scitranslmed.aal0033

Induction and suppression of NF-κB signalling by a DNA virus of Drosophila

Palmer WH, Joosten J, Overheul GJ, Jansen PW, Vermeulen M, Obbard DJ, Van Rij RP6 J Virol. 2018 Nov 7. pii: JVI.01443-18. doi: 10.1128/JVI.01443-18

Lack of IFNγ signaling attenuates spread of influenza A virus in vivo and leads to reduced pathogenesis

Nicol MQ, Campbell GM, Shaw DJ, Dransfield I, Ligertwood Y, Beard PM, Nash AA, Dutia BM. Virology. 2018 Oct 31;526:155-164. doi: 10.1016/j.virol.2018.10.017

Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules

Maizels RM, Smits HH and McSorley HJ; Immunity. 2018 Nov 20;49(5):801-818. doi: 10.1016/j.immuni.2018.10.016

Molecular identification of bovine trypanosomes in relation to cattle sources in southwest Nigeria

Odeniran PO, Macleod ET, Ademola IO and Welburn SC; Parasitol Int. 2018 Sep 20;68(1):1-8. doi: 10.1016/j.parint.2018.09.005

Natural Selection on Antihelminth Antibodies in a Wild Mammal Population

Sparks AM, Watt K, Sinclair R, Pilkington JG, Pemberton JM, Johnston SE, McNeilly TN, Nussey DH. Am Nat. 2018 Dec;192(6):745-760. doi: 10.1086/700115

Phenotypic and genetic variation in the response of chickens to Eimeria tenella induced coccidiosis.

Boulton K, Nolan MJ, Wu Z, Psifidi A, Riggio V, Harman K, Bishop SC, et al; Genet Sel Evol. 2018 Nov 21;50(1):63. doi: 10.1186/s12711-018-0433-7

Pneumonia: a global cause without champions

Watkins K, Sridhar D. Lancet. 2018 Sep 1;392(10149):718-719. doi: 10.1016/S0140-6736(18)31666-0

Population level changes in schistosome specific antibody levels following chemotherapy

Fukushige M, Mutapi F, Woolhouse MEJ; Parasite Immunol. 2018 Nov 22:e12604. doi: 10.1111/pim.12604

Staphylococcus pseudintermedius Surface Protein L (SpsL) Is Required for Abscess Formation in a Murine Cutaneous Infection Model

Richards AC, O'Shea M, Beard PM, Goncheva MI, Tuffs SW, Fitzgerald JR, Lengeling A, Infect Immun. 2018 Sep 4. pii: IAI.00631-18. doi: 10.1128/IAI.00631-18

The biofilm eradication activity of acetic acid in the management of periprosthetic joint infection

Tsang STJ, Gwynne PJ, Gallagher MP, Simpson AHRW; Bone Joint Res. 2018 Sep 15;7(8):517-523. doi: 10.1302/2046-3758.78.BJR-2018-0045.R1. eCollection 2018 Aug

The extricable links between health, wealth, and profits

Yamey G, Sridhar D, Abbasi K; BMJ. 2018 Oct 22;363:k4418. doi: 10.1136/bmj.k4418

The impact of anthelmintic drugs on weight gain of smallholder goats in subtropical regions

Bessell PR, Sargison ND, Mirende K, et al; Prev Vet Med. 2018 Nov 1;159:72-81. doi: 10.1016/j.prevetmed.2018.08.014

The Influence of Parasite Infections on Host Immunity to Co-infection With Other Pathogens

Mabbott NA; Front Immunol. 2018 Nov 8;9:2579. doi: 10.3389/fimmu.2018.02579

The kinetic characteristics of human and trypanosomatid phosphofructokinases for the reverse reaction

Fernandes PM, Kinkead JR, McNae IW, Michels PA, Walkinshaw MD; Biochem J. 2018 Nov 7. pii: BCJ20180635. doi: 10.1042/BCJ20180635

This article was published on 6 Dec, 2018

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