Edinburgh Infectious Diseases
EID logo 2019

Under-fives should be priority for snail fever therapy, study finds

Pre-school children in sub-Saharan Africa should be tested regularly for a common infection known as snail fever. Tests would reduce the spread of the disease while promoting childhood health and development.

Group of happy young African children
Infants in some of the world's poorest regions are vulnerable to a common worm parasite infection and their treatment should become a priority, according to a study.
Regular testing and treatment of pre-school children for snail fever - known as schistosomiasis or bilharzia - would reduce the spread of the disease, while promoting childhood health and development, experts have found.
The parasite, which is carried by freshwater snails, mainly infects people in sub-Saharan Africa. Once diagnosed, treatment with a cheap, readily available drug is usually effective.
Common symptoms include abdominal pain or blood in the urine. In children, it can cause stunted growth and learning difficulties. Infection acquired in childhood can cause bladder cancer and liver damage, or impact on reproductive health, in adults. 
Until now, pre-school children have not been routinely tested for nor treated for the condition, as the health impact of childhood infection has not been well understood.

We now know there is no such thing as snail fever without symptoms, and young children can get infected by snail fever very early in their lives."

Professor Francisca MutapiStudy leader, School of Biological Sciences, University of Edinburgh
In the first long-term study of the disease in this age group, researchers in the School of Biological Sciences, University of Edinburgh and their collaborators in Zimbabwe, monitored 1500 children aged from six months to five years old over the course of a year. 
Their research showed that children could contract an infection within their first year of life, and develop symptoms within three months. The study also highlighted for the first time that these infected children are at risk of malnutrition and stunted growth.  Treatment of the infection with the drug Praziquantel was shown to reverse symptoms. 

Our findings show that young children can develop clinical disease quickly, but existing diagnosis methods and treatments are effective in under-fives, which is welcome news for managing cases of infection in young children."

Derick OsakunorPhD student, School of Biological Sciences, University of Edinburgh
The study, funded by the Wellcome Trust and Thrasher Research Fund, was published in the BMJ Global Health.
Further information

Catriona Kelly, Press & PR office: 0131 651 4401; 07791 355940; Catriona.Kelly@ed.ac.uk

Parasite Immunology Group